Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9660829rdf:typepubmed:Citationlld:pubmed
pubmed-article:9660829lifeskim:mentionsumls-concept:C0036025lld:lifeskim
pubmed-article:9660829lifeskim:mentionsumls-concept:C0043393lld:lifeskim
pubmed-article:9660829lifeskim:mentionsumls-concept:C0024660lld:lifeskim
pubmed-article:9660829lifeskim:mentionsumls-concept:C0070348lld:lifeskim
pubmed-article:9660829lifeskim:mentionsumls-concept:C0439855lld:lifeskim
pubmed-article:9660829lifeskim:mentionsumls-concept:C1522492lld:lifeskim
pubmed-article:9660829lifeskim:mentionsumls-concept:C1334043lld:lifeskim
pubmed-article:9660829lifeskim:mentionsumls-concept:C1711351lld:lifeskim
pubmed-article:9660829pubmed:issue29lld:pubmed
pubmed-article:9660829pubmed:dateCreated1998-8-13lld:pubmed
pubmed-article:9660829pubmed:abstractTextThe PRT1, TIF34, GCD10, and SUI1 proteins of Saccharomyces cerevisiae were found previously to copurify with eukaryotic translation initiation factor 3 (eIF3) activity. Although TIF32, NIP1, and TIF35 are homologous to subunits of human eIF3, they were not known to be components of the yeast factor. We detected interactions between PRT1, TIF34, and TIF35 by the yeast two-hybrid assay and in vitro binding assays. Discrete segments (70-150 amino acids) of PRT1 and TIF35 were found to be responsible for their binding to TIF34. Temperature-sensitive mutations mapping in WD-repeat domains of TIF34 were isolated that decreased binding between TIF34 and TIF35 in vitro. The lethal effect of these mutations was suppressed by increasing TIF35 gene dosage, suggesting that the TIF34-TIF35 interaction is important for TIF34 function in translation. Pairwise in vitro interactions were also detected between PRT1 and TIF32, TIF32 and NIP1, and NIP1 and SUI1. Furthermore, PRT1, NIP1, TIF34, TIF35, and a polypeptide with the size of TIF32 were specifically coimmunoprecipitated from the ribosomal salt wash fraction. We propose that all five yeast proteins homologous to human eIF3 subunits are components of a stable heteromeric complex in vivo and may comprise the conserved core of yeast eIF3.lld:pubmed
pubmed-article:9660829pubmed:languageenglld:pubmed
pubmed-article:9660829pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:citationSubsetIMlld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9660829pubmed:statusMEDLINElld:pubmed
pubmed-article:9660829pubmed:monthJullld:pubmed
pubmed-article:9660829pubmed:issn0021-9258lld:pubmed
pubmed-article:9660829pubmed:authorpubmed-author:AndersonJJlld:pubmed
pubmed-article:9660829pubmed:authorpubmed-author:AsanoKKlld:pubmed
pubmed-article:9660829pubmed:authorpubmed-author:HinnebuschA...lld:pubmed
pubmed-article:9660829pubmed:authorpubmed-author:PhanLLlld:pubmed
pubmed-article:9660829pubmed:issnTypePrintlld:pubmed
pubmed-article:9660829pubmed:day17lld:pubmed
pubmed-article:9660829pubmed:volume273lld:pubmed
pubmed-article:9660829pubmed:ownerNLMlld:pubmed
pubmed-article:9660829pubmed:authorsCompleteYlld:pubmed
pubmed-article:9660829pubmed:pagination18573-85lld:pubmed
pubmed-article:9660829pubmed:dateRevised2009-7-21lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:meshHeadingpubmed-meshheading:9660829-...lld:pubmed
pubmed-article:9660829pubmed:year1998lld:pubmed
pubmed-article:9660829pubmed:articleTitleComplex formation by all five homologues of mammalian translation initiation factor 3 subunits from yeast Saccharomyces cerevisiae.lld:pubmed
pubmed-article:9660829pubmed:affiliationLaboratory of Eukaryotic Gene Regulation, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA.lld:pubmed
pubmed-article:9660829pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9660829pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:9660829pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9660829pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:852371entrezgene:pubmedpubmed-article:9660829lld:entrezgene
entrez-gene:855177entrezgene:pubmedpubmed-article:9660829lld:entrezgene
entrez-gene:854543entrezgene:pubmedpubmed-article:9660829lld:entrezgene
entrez-gene:852039entrezgene:pubmedpubmed-article:9660829lld:entrezgene
entrez-gene:855357entrezgene:pubmedpubmed-article:9660829lld:entrezgene
entrez-gene:855477entrezgene:pubmedpubmed-article:9660829lld:entrezgene
entrez-gene:853317entrezgene:pubmedpubmed-article:9660829lld:entrezgene
entrez-gene:855663entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:9660829lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9660829lld:pubmed
More...