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pubmed-article:9659451pubmed:abstractTextSeveral studies have shown that increasing cGMP in the heart reduces contractility, however, decreasing basal cGMP levels have also been shown in some studies to reduce contractility. This study was designed to evaluate the hypothesis that decreasing basal levels of cGMP decreases ventricular contractility, and that this depressed function is associated with a decrease in cAMP.lld:pubmed
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pubmed-article:9659451pubmed:articleTitleGuanylyl cyclase inhibition reduces contractility and decreases cGMP and cAMP in isolated rat hearts.lld:pubmed
pubmed-article:9659451pubmed:affiliationDeborah Research Institute, Brown Mills, NJ 08015, USA.lld:pubmed
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