| pubmed-article:9654089 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9654089 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9654089 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9654089 | lifeskim:mentions | umls-concept:C0667830 | lld:lifeskim |
| pubmed-article:9654089 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:9654089 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9654089 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9654089 | pubmed:dateCreated | 1998-7-17 | lld:pubmed |
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| pubmed-article:9654089 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:abstractText | Fas (APO-1/CD95) is a transmembrane receptor protein which induces apoptosis upon activation. In apoptosis triggered by Fas, a subset of cysteine proteases designated caspases is activated, playing a central role as effector molecules. Among these caspases, human caspase-8 (FLICE/MACH/Mch5) has been isolated and shown to be indispensable for Fas-mediated apoptotic signaling. In this study, we isolated the mouse homologue to human caspase-8 from a BaF3 cell cDNA library. This molecule conserved the death effector domain (DED) and protease domain as detected in human caspase-8, and was capable of inducing apoptosis in KB and Rat-1 cells when overexpressed. Expression of caspase-8 was detected in the various tissues of adult mouse and in embryos at 9.5 days and 17.5 days of development by Northern-blot analysis. Further, we isolated a chromosomal gene for caspase-8 from a mouse genomic library and analyzed the genomic structure of the isolated gene. This gene consisted of eight exons and seven introns spanning about 26 kb in the coding region. | lld:pubmed |
| pubmed-article:9654089 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9654089 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9654089 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9654089 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:9654089 | pubmed:author | pubmed-author:TsukumoSS | lld:pubmed |
| pubmed-article:9654089 | pubmed:author | pubmed-author:SakamakiKK | lld:pubmed |
| pubmed-article:9654089 | pubmed:author | pubmed-author:YoneharaSS | lld:pubmed |
| pubmed-article:9654089 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9654089 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9654089 | pubmed:volume | 253 | lld:pubmed |
| pubmed-article:9654089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9654089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9654089 | pubmed:pagination | 399-405 | lld:pubmed |
| pubmed-article:9654089 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
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| pubmed-article:9654089 | pubmed:meshHeading | pubmed-meshheading:9654089-... | lld:pubmed |
| pubmed-article:9654089 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9654089 | pubmed:articleTitle | Molecular cloning and characterization of mouse caspase-8. | lld:pubmed |
| pubmed-article:9654089 | pubmed:affiliation | Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:9654089 | pubmed:publicationType | Journal Article | lld:pubmed |
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