| pubmed-article:9653094 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0024296 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:9653094 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9653094 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9653094 | pubmed:dateCreated | 1998-8-14 | lld:pubmed |
| pubmed-article:9653094 | pubmed:abstractText | Movement of T and B lymphocytes through secondary lymphoid tissues is likely to involve multiple cues that help the cells navigate to appropriate compartments. Epstein-Barr virus- induced molecule 1 (EBI-1) ligand chemokine (ELC/MIP3beta) is expressed constitutively within lymphoid tissues and may act as such a guidance cue. Here, we have isolated mouse ELC and characterized its expression pattern and chemotactic properties. ELC is expressed constitutively in dendritic cells within the T cell zone of secondary lymphoid tissues. Recombinant ELC was strongly chemotactic for naive (L-selectinhi) CD4 T cells and for CD8 T cells and weakly attractive for resting B cells and memory (L-selectinlo) CD4 T cells. After activation through the B cell receptor, the chemotactic response of B cells was enhanced. Like its human counterpart, murine ELC stimulated cells transfected with EBI-1/CC chemokine receptor 7 (CCR7). Our findings suggest a central role for ELC in promoting encounters between recirculating T cells and dendritic cells and in the migration of activated B cells into the T zone of secondary lymphoid tissues. | lld:pubmed |
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| pubmed-article:9653094 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9653094 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9653094 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9653094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9653094 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9653094 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9653094 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9653094 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9653094 | pubmed:author | pubmed-author:TangH LHL | lld:pubmed |
| pubmed-article:9653094 | pubmed:author | pubmed-author:CysterJ GJG | lld:pubmed |
| pubmed-article:9653094 | pubmed:author | pubmed-author:NgoV NVN | lld:pubmed |
| pubmed-article:9653094 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9653094 | pubmed:day | 6 | lld:pubmed |
