| pubmed-article:9648069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C0041956 | lld:lifeskim |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C0205092 | lld:lifeskim |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:9648069 | lifeskim:mentions | umls-concept:C1413153 | lld:lifeskim |
| pubmed-article:9648069 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9648069 | pubmed:dateCreated | 1998-9-16 | lld:pubmed |
| pubmed-article:9648069 | pubmed:abstractText | Unilateral ureteral obstruction (UUO) is a well established experimental model of renal injury leading to interstitial fibrosis. The molecular and cellular mechanism(s) of interstitial fibrosis in UUO are beginning to be elucidated. In the progression of interstitial fibrosis in UUO, up-regulation of collagen synthesis is commonly observed. HSP47 is a collagen-binding stress protein and is thought to be a collagen-specific molecular chaperone, which plays a pivotal role during the biosynthesis and secretion of collagen molecules in the endoplasmic reticulum. The synthesis of HSP47 has been demonstrated to always parallel that of collagen in physiological and pathophysiological conditions. It is well recognized that renin-angiotensin system (RAS) is enhanced in the setting of UUO and that enhanced RAS has been implicated in the pathogenesis of interstitial fibrosis in the obstructed kidneys. | lld:pubmed |
| pubmed-article:9648069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9648069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9648069 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9648069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9648069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9648069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9648069 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9648069 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:AndoAA | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:NagataKK | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:HoriMM | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:MoriyamaTT | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:ImaiEE | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:YamauchiAA | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:HorioMM | lld:pubmed |
| pubmed-article:9648069 | pubmed:author | pubmed-author:KawadaNN | lld:pubmed |
| pubmed-article:9648069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9648069 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:9648069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9648069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9648069 | pubmed:pagination | 110-9 | lld:pubmed |
| pubmed-article:9648069 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:9648069 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9648069 | pubmed:articleTitle | Up-regulation of HSP47 in the mouse kidneys with unilateral ureteral obstruction. | lld:pubmed |
| pubmed-article:9648069 | pubmed:affiliation | First Department of Medicine, Osaka University School of Medicine, Faculty of Health and Sport Sciences, Japan. toshiki@medone.med.osaka-u.ac.jp | lld:pubmed |
| pubmed-article:9648069 | pubmed:publicationType | Journal Article | lld:pubmed |
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