| pubmed-article:9645713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0021463 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0050668 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0060623 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C2250368 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:9645713 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9645713 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9645713 | pubmed:dateCreated | 1998-7-17 | lld:pubmed |
| pubmed-article:9645713 | pubmed:abstractText | Activins and follistatins regulate all levels of the reproductive axis, including the pituitary where they stimulate and inhibit FSH production, respectively. Gonadotropes are known to express inhibin/activin betaB and activin-B (betaBbetaB) functions as an autocrine modulator of FSH production. By contrast, the mRNA for the activin-binding protein, follistatin, is present in most pituitary cells and folliculo-stellate cells may be the major source of the protein secreted by the anterior pituitary. Interleukin-1beta (IL-1beta) is one of several cytokines known to also influence the reproductive axis. IL-1beta inhibits the hypothalamo-pituitary-gonadal (HPG) axis by suppressing GnRH and gonadal steroid production. Because several pituitary cell types, including follistatin-producing folliculo-stellate cells, are targets of IL-1beta, cytokine effects on gonadotrope function were evaluated using cultured rat anterior pituitary cells. Activin-A (0.01 to 1 nM; 24h) increased basal FSH secretion approximately 2-fold. IL-1beta (0.005 to 0.5 nM) by itself had no effect on basal FSH secretion. However, IL-1beta attenuated FSH secretion in response to all concentrations of activin-A. These results suggest that the cytokine might stimulate the local production of a factor, such as follistatin, that antagonizes the action of activin-A. RNase protection analysis indicated that IL-1beta (0.005 to 5 nM) stimulated follistatin and inhibin/activin betaB mRNA accumulation in a time-dependent manner. These in vitro effects of IL-1beta were blocked by the specific IL-1 receptor antagonist (IL-lra) and were not mimicked by either rhIL-6 or lipopolysaccharide (LPS). Treatment of intact male rats with LPS (50 microg, i.v.), which increases plasma IL-1beta and induces IL-1beta expression in many tissues, including the pituitary, produced similar time-dependent increases in pituitary follistatin and inhibin/activin subunit mRNA levels. These results suggest that IL-1beta can modulate gonadotrope responses to activins by influencing the local balance of activin-B and follistatin within the pituitary. | lld:pubmed |
| pubmed-article:9645713 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9645713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9645713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9645713 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9645713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9645713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9645713 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9645713 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:9645713 | pubmed:author | pubmed-author:ValeW WWW | lld:pubmed |
| pubmed-article:9645713 | pubmed:author | pubmed-author:RivierC LCL | lld:pubmed |
| pubmed-article:9645713 | pubmed:author | pubmed-author:BilezikjianL... | lld:pubmed |
| pubmed-article:9645713 | pubmed:author | pubmed-author:BlountA LAL | lld:pubmed |
| pubmed-article:9645713 | pubmed:author | pubmed-author:CorriganA ZAZ | lld:pubmed |
| pubmed-article:9645713 | pubmed:author | pubmed-author:TurnbullA VAV | lld:pubmed |
| pubmed-article:9645713 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9645713 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:9645713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9645713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9645713 | pubmed:pagination | 3361-4 | lld:pubmed |
| pubmed-article:9645713 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9645713 | pubmed:meshHeading | pubmed-meshheading:9645713-... | lld:pubmed |
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| pubmed-article:9645713 | pubmed:meshHeading | pubmed-meshheading:9645713-... | lld:pubmed |
| pubmed-article:9645713 | pubmed:meshHeading | pubmed-meshheading:9645713-... | lld:pubmed |
| pubmed-article:9645713 | pubmed:meshHeading | pubmed-meshheading:9645713-... | lld:pubmed |
| pubmed-article:9645713 | pubmed:meshHeading | pubmed-meshheading:9645713-... | lld:pubmed |
| pubmed-article:9645713 | pubmed:meshHeading | pubmed-meshheading:9645713-... | lld:pubmed |
| pubmed-article:9645713 | pubmed:meshHeading | pubmed-meshheading:9645713-... | lld:pubmed |
| pubmed-article:9645713 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9645713 | pubmed:articleTitle | Interleukin-1beta regulates pituitary follistatin and inhibin/activin betaB mRNA levels and attenuates FSH secretion in response to activin-A. | lld:pubmed |
| pubmed-article:9645713 | pubmed:affiliation | Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:9645713 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9645713 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9645713 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9645713 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9645713 | lld:pubmed |
