| pubmed-article:9639295 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9639295 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:9639295 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:9639295 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9639295 | lifeskim:mentions | umls-concept:C0439611 | lld:lifeskim |
| pubmed-article:9639295 | lifeskim:mentions | umls-concept:C0290799 | lld:lifeskim |
| pubmed-article:9639295 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9639295 | pubmed:dateCreated | 1998-9-17 | lld:pubmed |
| pubmed-article:9639295 | pubmed:abstractText | No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the presence of Kryptofix 222 and K2CO3 by microwave heating (3 min, 500 W) using a remotely controlled radiosynthesis. Baseline separation of p-[18F]MPPF from the nitro derivative was performed on a semipreparative HPLC C18 column. After Sep-Pak formulation, the radiopharmaceutical was obtained with a radiochemical yield of 25% (EOS) in about 70 min. Specific radioactivity averaged between 1-5 Ci/micromol EOS. Labelling of the ortho and meta derivatives was also attempted. Brain uptake of p-[18F]MPPF was studied with PET on fluothane-anesthetized cats. Following intravenous injection of p-[18F]MPPF, high accumulation of radioactivity was observed in the hippocampus and cerebral cortex. Low levels of radioactivity were observed in cerebellum. At 30 min, the mean hippocampus/cerebellum and cortex/cerebellum ratios were 5 and 3.8, respectively. The accumulation of the tracer was blocked by prior administration of reference WAY-100635, demonstrating the specificity of the ligand. | lld:pubmed |
| pubmed-article:9639295 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9639295 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9639295 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9639295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9639295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9639295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9639295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9639295 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9639295 | pubmed:month | May | lld:pubmed |
| pubmed-article:9639295 | pubmed:issn | 0969-8051 | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:PujolJ FJF | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:Le BarsDD | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:LevielVV | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:ComarDD | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:BENYOE AEA | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:LemaireCC | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:BrihayeCC | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:PlenevauxAA | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:LuxenAA | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:WeissmannDD | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:GinovartNN | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:HassounWW | lld:pubmed |
| pubmed-article:9639295 | pubmed:author | pubmed-author:MekhsianPP | lld:pubmed |
| pubmed-article:9639295 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9639295 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:9639295 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9639295 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9639295 | pubmed:pagination | 343-50 | lld:pubmed |
| pubmed-article:9639295 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9639295 | pubmed:meshHeading | pubmed-meshheading:9639295-... | lld:pubmed |
| pubmed-article:9639295 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9639295 | pubmed:articleTitle | High-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635. | lld:pubmed |
| pubmed-article:9639295 | pubmed:affiliation | CERMEP, Lyon, France. lebars@univ-lyon1.fr | lld:pubmed |
| pubmed-article:9639295 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9639295 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9639295 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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