| pubmed-article:9636359 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9636359 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9636359 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:9636359 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:9636359 | lifeskim:mentions | umls-concept:C0164198 | lld:lifeskim |
| pubmed-article:9636359 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9636359 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:9636359 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9636359 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9636359 | pubmed:dateCreated | 1998-7-14 | lld:pubmed |
| pubmed-article:9636359 | pubmed:abstractText | The molecular chaperone cyclophilin A (Cyp A) modulates human immunodeficiency virus type 1 (HIV-1) infectivity through its interactions with Gag structural proteins. The molecular mechanism for CypA in HIV-1 replication is not known. We studied chaperone effects on Gag precursor processing using cyclosporin A (CsA) to bind CypA and prevent its interaction with p55Gag. CsA treatment inhibited p55Gag processing in extracellular virus-like particles produced from COS cells. We confirmed the effect of CsA on Gag processing by examining virions produced from CEMx174 cells infected with HIV-1LAI. Particles accumulated in the presence of CsA displayed mostly immature virion morphology and lacked condensed capsids. CsA has a direct effect on HIV-1 Gag processing that implicates CypA as having an important role in the maturation of HIV-1 particles. | lld:pubmed |
| pubmed-article:9636359 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636359 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636359 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9636359 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636359 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9636359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9636359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636359 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9636359 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9636359 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:9636359 | pubmed:author | pubmed-author:PauzaC DCD | lld:pubmed |
| pubmed-article:9636359 | pubmed:author | pubmed-author:MalkovskyMM | lld:pubmed |
| pubmed-article:9636359 | pubmed:author | pubmed-author:StreblowD NDN | lld:pubmed |
| pubmed-article:9636359 | pubmed:author | pubmed-author:KitabwallaMM | lld:pubmed |
| pubmed-article:9636359 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9636359 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:9636359 | pubmed:volume | 245 | lld:pubmed |
| pubmed-article:9636359 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9636359 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9636359 | pubmed:pagination | 197-202 | lld:pubmed |
| pubmed-article:9636359 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
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| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:meshHeading | pubmed-meshheading:9636359-... | lld:pubmed |
| pubmed-article:9636359 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9636359 | pubmed:articleTitle | Cyclophilin a modulates processing of human immunodeficiency virus type 1 p55Gag: mechanism for antiviral effects of cyclosporin A. | lld:pubmed |
| pubmed-article:9636359 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53706, USA. | lld:pubmed |
| pubmed-article:9636359 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9636359 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9636359 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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