Linked Life Data

9636152

Source:http://linkedlifedata.com/resource/pubmed/id/9636152

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pubmed-article:9636152pubmed:abstractTextThe intracellular signals governing cellular proliferation and developmental progression during lymphocyte development are incompletely understood. The tyrosine kinase Blk is expressed preferentially in the B lineage, but its function in B cell development has been largely unexplored. We have generated transgenic mice expressing constitutively active Blk [Blk(Y495F)] in the B and T lymphoid compartments. Expression of Blk(Y495F) in the B lineage at levels similar to that of endogenous Blk induced B lymphoid tumors of limited clonality, whose phenotypes are characteristic of B cell progenitors at the proB/preB-I to preB-II transition. Expression of constitutively active Blk in the T lineage resulted in the appearance of clonal, thymic lymphomas composed of intermediate single positive cells. Taken together, these results indicate that specific B and T cell progenitor subsets are preferentially susceptible to transformation by Blk(Y495F) and suggest a role for Blk in the control of proliferation during B cell development.lld:pubmed
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pubmed-article:9636152pubmed:articleTitleMalignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.lld:pubmed
pubmed-article:9636152pubmed:affiliationDepartment of Molecular Biology and Genetics and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.lld:pubmed
pubmed-article:9636152pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9636152pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9636152pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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