pubmed-article:9636152 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9636152 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:9636152 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
pubmed-article:9636152 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
pubmed-article:9636152 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
pubmed-article:9636152 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
pubmed-article:9636152 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:9636152 | lifeskim:mentions | umls-concept:C1518071 | lld:lifeskim |
pubmed-article:9636152 | pubmed:issue | 13 | lld:pubmed |
pubmed-article:9636152 | pubmed:dateCreated | 1998-8-6 | lld:pubmed |
pubmed-article:9636152 | pubmed:abstractText | The intracellular signals governing cellular proliferation and developmental progression during lymphocyte development are incompletely understood. The tyrosine kinase Blk is expressed preferentially in the B lineage, but its function in B cell development has been largely unexplored. We have generated transgenic mice expressing constitutively active Blk [Blk(Y495F)] in the B and T lymphoid compartments. Expression of Blk(Y495F) in the B lineage at levels similar to that of endogenous Blk induced B lymphoid tumors of limited clonality, whose phenotypes are characteristic of B cell progenitors at the proB/preB-I to preB-II transition. Expression of constitutively active Blk in the T lineage resulted in the appearance of clonal, thymic lymphomas composed of intermediate single positive cells. Taken together, these results indicate that specific B and T cell progenitor subsets are preferentially susceptible to transformation by Blk(Y495F) and suggest a role for Blk in the control of proliferation during B cell development. | lld:pubmed |
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pubmed-article:9636152 | pubmed:language | eng | lld:pubmed |
pubmed-article:9636152 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9636152 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9636152 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9636152 | pubmed:month | Jun | lld:pubmed |
pubmed-article:9636152 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:9636152 | pubmed:author | pubmed-author:ReidSS | lld:pubmed |
pubmed-article:9636152 | pubmed:author | pubmed-author:DesiderioSS | lld:pubmed |
pubmed-article:9636152 | pubmed:author | pubmed-author:MalekS NSN | lld:pubmed |
pubmed-article:9636152 | pubmed:author | pubmed-author:DintzisHH | lld:pubmed |
pubmed-article:9636152 | pubmed:author | pubmed-author:DordaiD IDI | lld:pubmed |
pubmed-article:9636152 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9636152 | pubmed:day | 23 | lld:pubmed |
pubmed-article:9636152 | pubmed:volume | 95 | lld:pubmed |
pubmed-article:9636152 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9636152 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9636152 | pubmed:pagination | 7351-6 | lld:pubmed |
pubmed-article:9636152 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:9636152 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:9636152 | pubmed:articleTitle | Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase. | lld:pubmed |
pubmed-article:9636152 | pubmed:affiliation | Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. | lld:pubmed |
pubmed-article:9636152 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9636152 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9636152 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:15218 | entrezgene:pubmed | pubmed-article:9636152 | lld:entrezgene |
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