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| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
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| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9636084 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:9636084 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:9636084 | pubmed:dateCreated | 1998-8-27 | lld:pubmed |
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| pubmed-article:9636084 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636084 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636084 | pubmed:abstractText | Pax-6 genes have been identified from a broad range of invertebrate and vertebrate animals and shown to be always involved in early eye development. Therefore, it has been proposed that the various types of eyes evolved from a single eye prototype, by a Pax-6-dependent mechanism. Here we describe the characterization of a cephalochordate Pax-6 gene. The single amphioxus Pax-6 gene (AmphiPax-6) can produce several alternatively spliced transcripts, resulting in proteins with markedly different amino and carboxy termini. The amphioxus Pax-6 proteins are 92% identical to mammalian Pax-6 proteins in the paired domain and 100% identical in the homeodomain. Expression of AmphiPax-6 in the anterior epidermis of embryos may be related to development of an olfactory epithelium. Expression is also detectable in Hatschek's left diverticulum as it forms the preoral ciliated pit, part of which gives rise to the homolog of the vertebrate anterior pituitary. A zone of expression in the anterior neural plate of early embryos is carried into the cerebral vesicle (a probable diencephalic homolog) during neurulation. This zone includes cells that will differentiate into the lamellar body, a presumed homolog of the vertebrate pineal eye. In neurulae, AmphiPax-6 is also expressed in ventral cells at the anterior tip of the nerve cord; these cells are precursors of the photoreceptive neurons of the frontal eye, the presumed homolog of the vertebrate paired eyes. However, AmphiPax-6 expression was not detected in two additional types of photoreceptors, the Joseph cells or the organs of Hesse, which are evidently relatively recent adaptations (ganglionic photoreceptors) and appear to be rare exceptions to the general rule that animal photoreceptors develop from a genetic program triggered by Pax-6. | lld:pubmed |
| pubmed-article:9636084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9636084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9636084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9636084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9636084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9636084 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9636084 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:9636084 | pubmed:author | pubmed-author:HollandL ZLZ | lld:pubmed |
| pubmed-article:9636084 | pubmed:author | pubmed-author:GehringW JWJ | lld:pubmed |
| pubmed-article:9636084 | pubmed:author | pubmed-author:HollandN DND | lld:pubmed |
| pubmed-article:9636084 | pubmed:author | pubmed-author:GlardonSS | lld:pubmed |
| pubmed-article:9636084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9636084 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:9636084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9636084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9636084 | pubmed:pagination | 2701-10 | lld:pubmed |
| pubmed-article:9636084 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9636084 | pubmed:meshHeading | pubmed-meshheading:9636084-... | lld:pubmed |
| pubmed-article:9636084 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9636084 | pubmed:articleTitle | Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution. | lld:pubmed |
| pubmed-article:9636084 | pubmed:affiliation | Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. | lld:pubmed |
| pubmed-article:9636084 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9636084 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9636084 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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