| pubmed-article:9632375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9632375 | lifeskim:mentions | umls-concept:C0019225 | lld:lifeskim |
| pubmed-article:9632375 | lifeskim:mentions | umls-concept:C0114838 | lld:lifeskim |
| pubmed-article:9632375 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:9632375 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:9632375 | lifeskim:mentions | umls-concept:C0376211 | lld:lifeskim |
| pubmed-article:9632375 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:9632375 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:9632375 | pubmed:dateCreated | 1998-7-9 | lld:pubmed |
| pubmed-article:9632375 | pubmed:abstractText | All four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2. 1]heptane were synthesized and evaluated as cocaine binding site ligands at the dopamine transporter. The in vitro binding affinities (Ki) of the 7-azabicyclo[2.2.1]heptane derivatives were measured in rat caudate-putamen tissue and found to be 100-3000-fold less potent (Ki = 5-96 microM) than cocaine and 2beta-(methoxycarbonyl)-3beta-phenyltropane (2, WIN 35,065-2). Surprisingly, the 3alpha-phenyl isomers (6c, 6d) were more potent than the 3beta-phenyl isomers (6a, 6b). Molecular modeling studies revealed that the rigid 7-azabicyclo[2.2.1]heptane derivatives possess molecular topologies which are significantly different than the molecular topologies of the 2beta-(methoxycarbonyl)-3-phenyltropanes. | lld:pubmed |
| pubmed-article:9632375 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9632375 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9632375 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9632375 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:9632375 | pubmed:author | pubmed-author:KatzJ LJL | lld:pubmed |
| pubmed-article:9632375 | pubmed:author | pubmed-author:ZhangCC | lld:pubmed |
| pubmed-article:9632375 | pubmed:author | pubmed-author:TrudellM LML | lld:pubmed |
| pubmed-article:9632375 | pubmed:author | pubmed-author:IzenwasserSS | lld:pubmed |
| pubmed-article:9632375 | pubmed:author | pubmed-author:TerryP DPD | lld:pubmed |
| pubmed-article:9632375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9632375 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:9632375 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:9632375 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9632375 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9632375 | pubmed:pagination | 2430-5 | lld:pubmed |
| pubmed-article:9632375 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
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| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
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| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:meshHeading | pubmed-meshheading:9632375-... | lld:pubmed |
| pubmed-article:9632375 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9632375 | pubmed:articleTitle | Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane. | lld:pubmed |
| pubmed-article:9632375 | pubmed:affiliation | Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA. | lld:pubmed |
| pubmed-article:9632375 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9632375 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9632375 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:9632375 | lld:chembl |
