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pubmed-article:9627121pubmed:abstractTextTwenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. CIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six (one with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.lld:pubmed
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pubmed-article:9627121pubmed:articleTitleAllelic deletion at 11q23.3-q25 is an early event in cervical neoplasia.lld:pubmed
pubmed-article:9627121pubmed:affiliationNuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Oxford, UK.lld:pubmed
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pubmed-article:9627121pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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