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pubmed-article:9626713pubmed:abstractTextIt has been suggested that patients with unipolar depression show abnormal responses to negative feedback in the performance of cognitive tasks. Positron emission tomography (PET) has previously identified blood flow abnormalities in depressed patients during cognitive performance. We have also used PET to identify regions where there is differential neural response to performance feedback in normal volunteers. In this study we aimed to test the hypothesis that blood flow in these regions, the medial caudate and ventromedial prefrontal cortex, would be abnormal in depressed patients.lld:pubmed
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pubmed-article:9626713pubmed:articleTitleAbnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression.lld:pubmed
pubmed-article:9626713pubmed:affiliationWellcome Department of Cognitive Neurology, Institute of Neurology, London.lld:pubmed
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