| pubmed-article:9622603 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9622603 | lifeskim:mentions | umls-concept:C1882825 | lld:lifeskim |
| pubmed-article:9622603 | lifeskim:mentions | umls-concept:C0333051 | lld:lifeskim |
| pubmed-article:9622603 | lifeskim:mentions | umls-concept:C0065844 | lld:lifeskim |
| pubmed-article:9622603 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:9622603 | lifeskim:mentions | umls-concept:C1156659 | lld:lifeskim |
| pubmed-article:9622603 | lifeskim:mentions | umls-concept:C0234112 | lld:lifeskim |
| pubmed-article:9622603 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9622603 | pubmed:dateCreated | 1998-8-19 | lld:pubmed |
| pubmed-article:9622603 | pubmed:abstractText | Effects of methylcobalamin (methyl-B12), a putative drug for treating human circadian rhythm disorders, on the melatonin-induced circadian phase shifts were examined in the rat. An intraperitoneal injection of 1-100 microg/kg melatonin 2-h before the activity onset time (CT 10) induced phase advances of free-running activity rhythms in a dose-dependent manner (ED50=1.3 microg/kg). Injection of methyl-B12 (500 microg/kg) prior to melatonin (1 microg/kg) injection induced larger phase advances than saline preinjected controls, while the injection of methyl-B12 in combination with saline did not induce a phase advance. These results indicate amplification of melatonin-induced phase advances by methyl-B12. Pinealectomy abolished the phase alternating effect of methyl-B12, suggesting a site of action within the pineal gland. In fact, methyl-B12 significantly increased the content of melatonin in the pineal collected 2-h after activity onset (CT 14). In contrast, no difference in melatonin content was found at CT 10, indicating that the effect of methyl-B12 may be gated after the activity onset time when endogenous melatonin synthesis is known to increase. These results suggest that methyl-B12 amplifies melatonin-induced phase advances via an increase in melatonin synthesis during the early subjective night at a point downstream from the clock regulation. | lld:pubmed |
| pubmed-article:9622603 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9622603 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9622603 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9622603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9622603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9622603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9622603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9622603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9622603 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9622603 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9622603 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:9622603 | pubmed:author | pubmed-author:IkedaMM | lld:pubmed |
| pubmed-article:9622603 | pubmed:author | pubmed-author:ShibataSS | lld:pubmed |
| pubmed-article:9622603 | pubmed:author | pubmed-author:BUCHOO | lld:pubmed |
| pubmed-article:9622603 | pubmed:author | pubmed-author:SagaraMM | lld:pubmed |
| pubmed-article:9622603 | pubmed:author | pubmed-author:MoriyaTT | lld:pubmed |
| pubmed-article:9622603 | pubmed:author | pubmed-author:InouéSS | lld:pubmed |
| pubmed-article:9622603 | pubmed:copyrightInfo | Copyright 1998 Elsevier Science B.V. All rights reserved. | lld:pubmed |
| pubmed-article:9622603 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9622603 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:9622603 | pubmed:volume | 795 | lld:pubmed |
| pubmed-article:9622603 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9622603 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9622603 | pubmed:pagination | 98-104 | lld:pubmed |
| pubmed-article:9622603 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:meshHeading | pubmed-meshheading:9622603-... | lld:pubmed |
| pubmed-article:9622603 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9622603 | pubmed:articleTitle | Methylcobalamin amplifies melatonin-induced circadian phase shifts by facilitation of melatonin synthesis in the rat pineal gland. | lld:pubmed |
| pubmed-article:9622603 | pubmed:affiliation | Advanced Research Center for Human Sciences, Waseda University, Saitama, Japan. msikeda@mn.waseda.ac.jp | lld:pubmed |
| pubmed-article:9622603 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9622603 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
