| pubmed-article:9600271 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9600271 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9600271 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:9600271 | lifeskim:mentions | umls-concept:C0037657 | lld:lifeskim |
| pubmed-article:9600271 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:9600271 | lifeskim:mentions | umls-concept:C0336791 | lld:lifeskim |
| pubmed-article:9600271 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9600271 | pubmed:dateCreated | 1998-6-10 | lld:pubmed |
| pubmed-article:9600271 | pubmed:abstractText | Cell systems derived from knockout mice for the insulin receptor (IR) or the IGF-1 receptor (IGF-1R) represent unique tools for dissecting complex interplay in the actions of insulin and insulin-like growth factors through their cognate versus non-cognate receptor. In this study, we used a fibroblast cell line derived from IR-deficient mice to investigate metabolic and mitogenic effects of IGF-1 and insulin. IGF-1 was able to stimulate glucose uptake, glucose incorporation into glycogen and thymidine incorporation in such cells. Phosphatidylinositol 3-kinase and mitogen-activated protein kinase, two enzymes of major metabolic-mitogenic signaling pathways, were activated upon stimulating these cells with IGF-1. All these effects were also achieved when IR-deficient cells were stimulated with insulin. Thus, IGF-1R can represent an alternative receptor through which insulin might exert some of its effects. | lld:pubmed |
| pubmed-article:9600271 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9600271 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600271 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9600271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600271 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600271 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9600271 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9600271 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9600271 | pubmed:author | pubmed-author:De MeytsPP | lld:pubmed |
| pubmed-article:9600271 | pubmed:author | pubmed-author:JamiJJ | lld:pubmed |
| pubmed-article:9600271 | pubmed:author | pubmed-author:BucchiniDD | lld:pubmed |
| pubmed-article:9600271 | pubmed:author | pubmed-author:JoshiR LRL | lld:pubmed |
| pubmed-article:9600271 | pubmed:author | pubmed-author:BaudryAA | lld:pubmed |
| pubmed-article:9600271 | pubmed:author | pubmed-author:Christofferse... | lld:pubmed |
| pubmed-article:9600271 | pubmed:author | pubmed-author:LamotheBB | lld:pubmed |
| pubmed-article:9600271 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9600271 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9600271 | pubmed:volume | 426 | lld:pubmed |
| pubmed-article:9600271 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9600271 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9600271 | pubmed:pagination | 381-5 | lld:pubmed |
| pubmed-article:9600271 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:meshHeading | pubmed-meshheading:9600271-... | lld:pubmed |
| pubmed-article:9600271 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9600271 | pubmed:articleTitle | Insulin receptor-deficient cells as a new tool for dissecting complex interplay in insulin and insulin-like growth factors. | lld:pubmed |
| pubmed-article:9600271 | pubmed:affiliation | Institut Cochin de Génétique Moléculaire, INSERM U257, Paris, France. | lld:pubmed |
| pubmed-article:9600271 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9600271 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9600271 | lld:pubmed |
