| pubmed-article:9598457 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C0011311 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C1622204 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:9598457 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:9598457 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9598457 | pubmed:dateCreated | 1998-6-1 | lld:pubmed |
| pubmed-article:9598457 | pubmed:abstractText | A recombinant protein containing part of the dengue (DEN) 2 envelope protein was evaluated as a subunit immunogen for vaccination against DEN virus infection. A gene fragment encoding amino acids 298-400 (B domain) of the DEN-2 virus envelope was expressed as a fusion protein with the maltose binding protein (MBP) of Escherichia coli. This recombinant, DEN-2(B)/MBP, was purified and analyzed for its antigenicity, immunogenicity, and ability to protect mice against lethal challenge. The recombinant antigen reacted with a DEN-2 type-specific neutralizing monoclonal antibody (3H5), DEN-2 hyperimmune mouse ascitic fluid, and DEN-2 immune human sera. When administered to mice, DEN-2(B)/MBP elicited a DEN-2 virus neutralizing antibody response that conferred partial protection against challenge infection with a lethal dose of DEN-2 virus administered by intracranial inoculation. In addition, no replication of DEN-2 virus was detectable in the brains of the immunized mice as compared with control mice that were killed six days after challenge. Sera from immunized mice revealed no cross-neutralizing antibody to any of the other DEN serotypes in the plaque-reduction neutralization test. These findings warrant further studies with the DEN-2(B)/MBP antigen as a potential human vaccine candidate. An effective vaccine could prevent thousands of cases of illness and many deaths each year resulting from DEN virus infections. | lld:pubmed |
| pubmed-article:9598457 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9598457 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9598457 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9598457 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9598457 | pubmed:month | May | lld:pubmed |
| pubmed-article:9598457 | pubmed:issn | 0002-9637 | lld:pubmed |
| pubmed-article:9598457 | pubmed:author | pubmed-author:HayesC GCG | lld:pubmed |
| pubmed-article:9598457 | pubmed:author | pubmed-author:ODAOO | lld:pubmed |
| pubmed-article:9598457 | pubmed:author | pubmed-author:SimmonsMM | lld:pubmed |
| pubmed-article:9598457 | pubmed:author | pubmed-author:NelsonW MWM | lld:pubmed |
| pubmed-article:9598457 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9598457 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:9598457 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9598457 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9598457 | pubmed:pagination | 655-62 | lld:pubmed |
| pubmed-article:9598457 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9598457 | pubmed:meshHeading | pubmed-meshheading:9598457-... | lld:pubmed |
| pubmed-article:9598457 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9598457 | pubmed:articleTitle | Evaluation of the protective efficacy of a recombinant dengue envelope B domain fusion protein against dengue 2 virus infection in mice. | lld:pubmed |
| pubmed-article:9598457 | pubmed:affiliation | Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA. | lld:pubmed |
| pubmed-article:9598457 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9598457 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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