Linked Life Data

9596807

Source:http://linkedlifedata.com/resource/pubmed/id/9596807

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pubmed-article:9596807pubmed:abstractText1. The ability of the fetal adrenal medulla to respond directly to hypoxaemia and secrete catecholamines before the development of a functional innervation of the gland is essential for intrauterine survival. The cellular mechanisms involved in this response to low PO2 are not known, although the presence of oxygen-sensitive K+ channels in carotid body chemoreceptor cells and other sites suggests that these might underlie the chromaffin cell response. 2. Whole-cell patch-clamp techniques have been used to study K+ currents during normoxia and hypoxia in chromaffin cells isolated from the adrenal glands of fetal sheep. 3. Two types of chromaffin cells were observed, those with a fast inactivating K+ current and a larger capacitance and those with a delayed K+ current and smaller capacitance. No cell showed both types of current. The fast inactivating current showed voltage-dependent inactivation and was blocked by 1 mM 4-aminopyridine, characteristics of an IA-type current. The delayed current had two components, a TEA-sensitive, Ca2+-dependent current and a component with the kinetic behaviour of a delayed rectifier. 4. Both types of current were oxygen sensitive. The IA-type current was reduced by 27.4 +/- 3.2 % when the PO2 was reduced to about 15 mmHg. With the delayed current, hypoxia reduced the amplitude by 26.9 +/- 2.4 %, largely by reduction of the Ca2+-dependent component. 5. In the presence of hypoxia, reduction in the amplitude of these oxygen-sensitive K+ currents would increase the frequency and duration of action potentials, leading to increased activation of the L-type Ca2+ channels, influx of Ca2+ and the subsequent secretion of catecholamines.lld:pubmed
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pubmed-article:9596807pubmed:authorpubmed-author:RobertsM LMLlld:pubmed
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pubmed-article:9596807pubmed:articleTitleOxygen-sensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth.lld:pubmed
pubmed-article:9596807pubmed:affiliationDepartment of Physiology, University of Adelaide, Adelaide 5005, Australia.lld:pubmed
pubmed-article:9596807pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9596807pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9596807pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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