| pubmed-article:9592156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9592156 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:9592156 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:9592156 | lifeskim:mentions | umls-concept:C0039808 | lld:lifeskim |
| pubmed-article:9592156 | lifeskim:mentions | umls-concept:C1881865 | lld:lifeskim |
| pubmed-article:9592156 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9592156 | pubmed:dateCreated | 1998-7-20 | lld:pubmed |
| pubmed-article:9592156 | pubmed:abstractText | Thermodynamics of 23 oligonucleotides with internal single C.T mismatches were obtained by measuring UV absorbance as a function of temperature. Results from these 23 duplexes were combined with three measurements from the literature to derive nearest-neighbor thermodynamic parameters for seven linearly independent trimer sequences with internal C.T mismatches. The data show that the nearest-neighbor model is adequate for predicting thermodynamics of oligonucleotides with internal C.T with average deviations for Delta G degrees37, Delta H degrees, Delta S degrees and T m of 6.4%, 9.9%, 10.6%, and 1.9 degreesC respectively. C.T mismatches destabilize the duplex in all sequence contexts. The thermodynamic contribution of C. T mismatches to duplex stability varies weakly depending on the orientation of the mismatch and its context and ranges from +1.02 kcal/mol for GCG/CTC and CCG/GTC to +1.95 kcal/mol for TCC/ATG. | lld:pubmed |
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| pubmed-article:9592156 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9592156 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9592156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9592156 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9592156 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:9592156 | pubmed:author | pubmed-author:SantaLuciaJJJ... | lld:pubmed |
| pubmed-article:9592156 | pubmed:author | pubmed-author:AllawiH THT | lld:pubmed |
| pubmed-article:9592156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9592156 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9592156 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:9592156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9592156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9592156 | pubmed:pagination | 2694-701 | lld:pubmed |
| pubmed-article:9592156 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9592156 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9592156 | pubmed:articleTitle | Thermodynamics of internal C.T mismatches in DNA. | lld:pubmed |
| pubmed-article:9592156 | pubmed:affiliation | Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. | lld:pubmed |
| pubmed-article:9592156 | pubmed:publicationType | Journal Article | lld:pubmed |
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