| pubmed-article:9585421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0005595 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0080091 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:9585421 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9585421 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9585421 | pubmed:dateCreated | 1998-6-17 | lld:pubmed |
| pubmed-article:9585421 | pubmed:abstractText | The cytokine Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) regulates proliferation, differentiation, and apoptosis during myelopoiesis and erythropoiesis. Structure-function relationships of GM-CSF interactions with its receptor (GM-R), the biochemistry of GM-R signal transduction, and GM-CSF action in vivo are relatively well understood. Much less is known, however, about GM-R function in primary hematopoietic cells. In this paper we show that expression of the human GM-R in a heterologous cell system (primary avian erythroid and myeloid cells) confirms respective results in murine or human cell lines, but also provides new insights how the GM-R regulates progenitor proliferation and differentiation. As expected, the hGM-CSF stimulated myeloid progenitor proliferation and differentiation and enhanced erythroid progenitor proliferation during terminal differentiation. In the latter cells, however, the hGM-R only partially substituted for the activities of the erythropoietin receptor (EpoR). It failed to replace the EpoR in its cooperation with c-Kit to induce long-term proliferation of erythroid progenitors. Furthermore, the hGM-R alpha chain specifically interfered with EpoR signaling, an activity neither seen for the betac subunit of the receptor complex alone, nor for the alpha chain of the closely related Interleukin-3 receptor. These results point to a novel role of the GM-R alpha chain in defining cell type-specific functions of the GM-R. | lld:pubmed |
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| pubmed-article:9585421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9585421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9585421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9585421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9585421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9585421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9585421 | pubmed:month | May | lld:pubmed |
| pubmed-article:9585421 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:9585421 | pubmed:author | pubmed-author:BeugHH | lld:pubmed |
| pubmed-article:9585421 | pubmed:author | pubmed-author:LieK KKK | lld:pubmed |
| pubmed-article:9585421 | pubmed:author | pubmed-author:SteinleinPP | lld:pubmed |
| pubmed-article:9585421 | pubmed:author | pubmed-author:MellitzerGG | lld:pubmed |
| pubmed-article:9585421 | pubmed:author | pubmed-author:DeinerE MEM | lld:pubmed |
| pubmed-article:9585421 | pubmed:author | pubmed-author:WesselyOO | lld:pubmed |
| pubmed-article:9585421 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9585421 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:9585421 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:9585421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9585421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9585421 | pubmed:pagination | 1041-51 | lld:pubmed |
| pubmed-article:9585421 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9585421 | pubmed:meshHeading | pubmed-meshheading:9585421-... | lld:pubmed |
