| pubmed-article:9584101 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0043157 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0017347 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0205095 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C1704448 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0220938 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0441587 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:9584101 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:9584101 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9584101 | pubmed:dateCreated | 1998-7-7 | lld:pubmed |
| pubmed-article:9584101 | pubmed:abstractText | We used the white gene as an enhancer trap and reporter of chromatin structure. We collected white+ transgene insertions presenting a peculiar pigmentation pattern in the eye: white expression is restricted to the dorsal half of the eye, with a clear-cut dorsal/ventral (D/V) border. This D/V pattern is stable and heritable, indicating that phenotypic expression of the white reporter reflects positional information in the developing eye. Localization of these transgenes led us to identify a unique genomic region encompassing 140 kb in 69D1-3 subject to this D/V effect. This region contains at least three closely related homeobox-containing genes that are constituents of the iroquois complex (IRO-C). IRO-C genes are coordinately regulated and implicated in similar developmental processes. Expression of these genes in the eye is regulated by the products of the Polycomb-group (Pc-G) and trithorax-group (trx-G) genes but is not modified by classical modifiers of position-effect variegation. Our results, together with the report of a Pc-G binding site in 69D, suggest that we have identified a novel cluster of target genes for the Pc-G and trx-G products. We thus propose that ventral silencing of the whole IRO-C in the eye occurs at the level of chromatin structure in a manner similar to that of the homeotic gene complexes, perhaps by local compaction of the region into a heterochromatin-like structure involving the Pc-G products. | lld:pubmed |
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| pubmed-article:9584101 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9584101 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9584101 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9584101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9584101 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
