Linked Life Data

9582443

Source:http://linkedlifedata.com/resource/pubmed/id/9582443

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pubmed-article:9582443pubmed:abstractTextIntra-hippocampal injection of NMDA (12.5 nmol) in postnatal day 7 (P7) rats results in neuronal necrosis and hippocampal atrophy; injury extends into the adjacent striatum, thalamus and cortex. NMDA-induced injury is marked by an acute microglial/monocyte response; the molecular signals that control this response and the role of activated microglia/monocytes in the progression of excitotoxic injury are unknown. Monocyte chemoattractant protein-1 (MCP-1) is a well-characterized chemokine that regulates monocyte chemotaxis and activation, and contributes to the pathogenesis of monocyte-dependent tissue injury in several disease models. We hypothesized that MCP-1 could be a regulator of the microglial/monocyte response to excitotoxic injury in neonatal rat brain. To determine if intra-hippocampal NMDA injections induced MCP-1 mRNA expression, in situ hybridization assays were performed in brain samples obtained from 7-day-old rats, evaluated 0-24 h after intra-hippocampal NMDA injection. MCP-1 mRNA expression was first detected at 2 h after lesioning, in the choroid fissure, adjacent to the lesioned hippocampus; levels of expression increased markedly in the lesioned hippocampus and adjacent structures within the first 16 h after NMDA injection, and then rapidly declined. In control animals that received intra-hippocampal saline injections, only minimal MCP-1 mRNA was detected, along the injection track. These results demonstrate that excitotoxic injury transiently induces MCP-1 gene expression in neonatal rat brain. The functional role of MCP-1 in the injured brain remains to be determined.lld:pubmed
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pubmed-article:9582443pubmed:authorpubmed-author:LiuX HXHlld:pubmed
pubmed-article:9582443pubmed:authorpubmed-author:IvackoJJlld:pubmed
pubmed-article:9582443pubmed:copyrightInfoCopyright 1998 Elsevier Science B.V.lld:pubmed
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pubmed-article:9582443pubmed:volume55lld:pubmed
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pubmed-article:9582443pubmed:pagination306-14lld:pubmed
pubmed-article:9582443pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9582443pubmed:articleTitleExcitotoxic injury induces monocyte chemoattractant protein-1 expression in neonatal rat brain.lld:pubmed
pubmed-article:9582443pubmed:affiliationDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.lld:pubmed
pubmed-article:9582443pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9582443pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9582443pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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