| pubmed-article:9581863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9581863 | lifeskim:mentions | umls-concept:C0001383 | lld:lifeskim |
| pubmed-article:9581863 | lifeskim:mentions | umls-concept:C0064634 | lld:lifeskim |
| pubmed-article:9581863 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:9581863 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:9581863 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9581863 | pubmed:dateCreated | 1998-6-10 | lld:pubmed |
| pubmed-article:9581863 | pubmed:abstractText | Even though the involvement of the 67-kDa laminin receptor (67LR) in tumor invasiveness has been clearly demonstrated, its molecular structure remains an open problem, since only a full-length gene encoding a 37-kDa precursor protein (37LRP) has been isolated so far. A pool of recently obtained monoclonal antibodies directed against the recombinant 37LRP molecule was used to investigate the processing that leads to the formation of the 67-kDa molecule. In soluble extracts of A431 human carcinoma cells, these reagents recognize the precursor molecule as well as the mature 67LR and a 120-kDa molecule. The recovery of these proteins was found to be strikingly dependent upon the cell solubilization conditions: the 67LR is soluble in NP-40-lysis buffer whereas the 37LRP is NP-40-insoluble. Inhibition of 67LR formation by cerulenin indicates that acylation is involved in the processing of the receptor. It is likely a palmitoylation process, as indicated by sensitivity of NP-40-soluble extracts to hydroxylamine treatment. Immunoblotting assays performed with a polyclonal serum directed against galectin3 showed that both the 67- and the 120-kDa proteins carry galectin3 epitopes whereas the 37LRP does not. These data suggest that the 67LR is a heterodimer stabilized by strong intramolecular hydrophobic interactions, carried by fatty acids bound to the 37LRP and to a galectin3 cross-reacting molecule. | lld:pubmed |
| pubmed-article:9581863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9581863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9581863 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9581863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9581863 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9581863 | pubmed:issn | 0730-2312 | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:SobelM EME | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:ColnaghiM IMI | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:MénardSS | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:TagliabueEE | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:CastronovoVV | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:ButòSS | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:MagnificoAA | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:ArdiniEE | lld:pubmed |
| pubmed-article:9581863 | pubmed:author | pubmed-author:GhirelliCC | lld:pubmed |
| pubmed-article:9581863 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9581863 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9581863 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:9581863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9581863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9581863 | pubmed:pagination | 244-51 | lld:pubmed |
| pubmed-article:9581863 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9581863 | pubmed:meshHeading | pubmed-meshheading:9581863-... | lld:pubmed |
| pubmed-article:9581863 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9581863 | pubmed:articleTitle | Formation of the 67-kDa laminin receptor by acylation of the precursor. | lld:pubmed |
| pubmed-article:9581863 | pubmed:affiliation | Division of Experimental Oncology E, Istituto Nazionale Tumori, Milan, Italy. | lld:pubmed |
| pubmed-article:9581863 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9581863 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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