Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9575947rdf:typepubmed:Citationlld:pubmed
pubmed-article:9575947lifeskim:mentionsumls-concept:C1522565lld:lifeskim
pubmed-article:9575947lifeskim:mentionsumls-concept:C0869014lld:lifeskim
pubmed-article:9575947lifeskim:mentionsumls-concept:C1515655lld:lifeskim
pubmed-article:9575947lifeskim:mentionsumls-concept:C0591833lld:lifeskim
pubmed-article:9575947pubmed:issue4 Pt 2lld:pubmed
pubmed-article:9575947pubmed:dateCreated1998-6-2lld:pubmed
pubmed-article:9575947pubmed:abstractTextThe mouse is the species of choice for creating genetically engineered models of human disease. To study detailed systolic and diastolic left ventricular (LV) chamber mechanics in mice in vivo, we developed a miniaturized conductance-manometer system. alpha-Chloralose-urethan-anesthetized animals were instrumented with a two-electrode pressure-volume catheter advanced via the LV apex to the aortic root. Custom electronics provided time-varying conductances related to cavity volume. Baseline hemodynamics were similar to values in conscious animals: 634 +/- 14 beats/min, 112 +/- 4 mmHg, 5.3 +/- 0.8 mmHg, and 11,777 +/- 732 mmHg/s for heart rate, end-systolic and end-diastolic pressures, and maximum first derivative of ventricular pressure with respect to time (dP/dtmax), respectively. Catheter stroke volume during preload reduction by inferior vena caval occlusion correlated with that by ultrasound aortic flow probe (r2 = 0.98). This maneuver yielded end-systolic elastances of 79 +/- 21 mmHg/microliter, preload-recruitable stroke work of 82 +/- 5.6 mmHg, and slope of dP/dtmax-end-diastolic volume relation of 699 +/- 100 mmHg.s-1.microliter-1, and these relations varied predictably with acute inotropic interventions. The control normalized time-varying elastance curve was similar to human data, further supporting comparable chamber mechanics between species. This novel approach should greatly help assess cardiovascular function in the blood-perfused murine heart.lld:pubmed
pubmed-article:9575947pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9575947pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9575947pubmed:languageenglld:pubmed
pubmed-article:9575947pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9575947pubmed:citationSubsetIMlld:pubmed
pubmed-article:9575947pubmed:statusMEDLINElld:pubmed
pubmed-article:9575947pubmed:monthAprlld:pubmed
pubmed-article:9575947pubmed:issn0002-9513lld:pubmed
pubmed-article:9575947pubmed:authorpubmed-author:ChenC HCHlld:pubmed
pubmed-article:9575947pubmed:authorpubmed-author:ByrneB JBJlld:pubmed
pubmed-article:9575947pubmed:authorpubmed-author:MitznerW AWAlld:pubmed
pubmed-article:9575947pubmed:authorpubmed-author:KassD ADAlld:pubmed
pubmed-article:9575947pubmed:authorpubmed-author:MillarH DHDlld:pubmed
pubmed-article:9575947pubmed:authorpubmed-author:Georgakopoulo...lld:pubmed
pubmed-article:9575947pubmed:authorpubmed-author:GubaM IMIlld:pubmed
pubmed-article:9575947pubmed:issnTypePrintlld:pubmed
pubmed-article:9575947pubmed:volume274lld:pubmed
pubmed-article:9575947pubmed:ownerNLMlld:pubmed
pubmed-article:9575947pubmed:authorsCompleteYlld:pubmed
pubmed-article:9575947pubmed:paginationH1416-22lld:pubmed
pubmed-article:9575947pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:meshHeadingpubmed-meshheading:9575947-...lld:pubmed
pubmed-article:9575947pubmed:year1998lld:pubmed
pubmed-article:9575947pubmed:articleTitleIn vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry.lld:pubmed
pubmed-article:9575947pubmed:affiliationDepartment of Medicine, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.lld:pubmed
pubmed-article:9575947pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9575947pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9575947lld:pubmed