| pubmed-article:9575877 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9575877 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:9575877 | lifeskim:mentions | umls-concept:C0538674 | lld:lifeskim |
| pubmed-article:9575877 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9575877 | pubmed:issue | 4 Pt 1 | lld:pubmed |
| pubmed-article:9575877 | pubmed:dateCreated | 1998-6-2 | lld:pubmed |
| pubmed-article:9575877 | pubmed:abstractText | Heme oxygenase (HO)-1, which catalyzes heme breakdown, is induced by oxidative stress and may protect against oxidative injury. We hypothesized that induction of HO-1 by hemoglobin (Hb) in the lung would protect the rat from pulmonary O2 toxicity. Rats given intratracheal (i.t.) Hb showed lung-specific induction of HO-1 by 8 h by Western analysis. Rats were then pretreated for 8 h before 60 h of exposure to 100% O2 with either IT normal saline, HB, or Hb plus the HO-1 inhibitor tinprotoporphyrin (SnPP). Both the Hb + O2 and Hb + O2 + SnPP animals had less lung injury than normal saline controls as indicated by lower pleural fluid volumes and wet-to-dry weight ratios (P < 0.01). The improvement in injury in the two Hb-treated groups was the same despite a 61% decrease in HO enzyme activity in the Hb + SnPP group after 60 h of O2. In addition, inhibition of HO activity with SnPP alone before O2 exposure did not augment the extent of hyperoxic lung injury. These results demonstrate that IT Hb induces lung HO-1 in the rat and protects against hyperoxia; however, the protection is not mediated by increased HO enzyme activity. | lld:pubmed |
| pubmed-article:9575877 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9575877 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9575877 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9575877 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9575877 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9575877 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9575877 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9575877 | pubmed:author | pubmed-author:TaylorJ LJL | lld:pubmed |
| pubmed-article:9575877 | pubmed:author | pubmed-author:PiantadosiC... | lld:pubmed |
| pubmed-article:9575877 | pubmed:author | pubmed-author:CarrawayM SMS | lld:pubmed |
| pubmed-article:9575877 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9575877 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:9575877 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9575877 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9575877 | pubmed:pagination | L582-90 | lld:pubmed |
| pubmed-article:9575877 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9575877 | pubmed:meshHeading | pubmed-meshheading:9575877-... | lld:pubmed |
| pubmed-article:9575877 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9575877 | pubmed:articleTitle | Lung-specific induction of heme oxygenase-1 and hyperoxic lung injury. | lld:pubmed |
| pubmed-article:9575877 | pubmed:affiliation | Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. | lld:pubmed |
| pubmed-article:9575877 | pubmed:publicationType | Journal Article | lld:pubmed |
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