| pubmed-article:9574553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0008679 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0030664 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0036330 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C1611645 | lld:lifeskim |
| pubmed-article:9574553 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:9574553 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9574553 | pubmed:dateCreated | 1998-5-21 | lld:pubmed |
| pubmed-article:9574553 | pubmed:abstractText | We have used IL-10 gene knockout mice (IL-10T) to examine the role of endogenous IL-10 in the down-modulation of hepatic granuloma formation and lymphocyte responses that occurs in chronic infection with the helminth parasite Schistosoma mansoni. Although IL-10-deficient animals showed 20 to 30% mortality between 8 and 14 wk postinfection, they displayed no alterations in their susceptibility to infection and produced similar numbers of eggs as their wild-type littermates. The IL-10T mice displayed a significant increase in hepatic granuloma size at the acute stage of infection, which was associated with increased IFN-gamma, IL-2, IL-1beta, and TNF-alpha mRNA expression in liver and elevated Th1-type cytokine production by lymphoid cells. Despite developing an enhanced Th1-type cytokine response, the IL-10T mice showed no consistent decrease in their Th2-type cytokine profile. Surprisingly, although granulomatous inflammation was enhanced at the acute stage of infection, the livers of IL-10T mice displayed no significant increase in fibrosis and underwent normal immune down-modulation at the chronic stage of infection. Moreover, the down-modulated state could be induced in IL-10T mice by sensitizing the animals to schistosome eggs before infection, further demonstrating that the major down-regulatory mechanism is not dependent upon IL-10. We conclude that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection. | lld:pubmed |
| pubmed-article:9574553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9574553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9574553 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9574553 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9574553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9574553 | pubmed:month | May | lld:pubmed |
| pubmed-article:9574553 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:MüllerWW | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:SherAA | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:CheeverA WAW | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:WilliamsM EME | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:KühnRR | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:WynnT ATA | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:HienySS | lld:pubmed |
| pubmed-article:9574553 | pubmed:author | pubmed-author:CasparPP | lld:pubmed |
| pubmed-article:9574553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9574553 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9574553 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:9574553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9574553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9574553 | pubmed:pagination | 4473-80 | lld:pubmed |
| pubmed-article:9574553 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9574553 | pubmed:meshHeading | pubmed-meshheading:9574553-... | lld:pubmed |
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| pubmed-article:9574553 | pubmed:meshHeading | pubmed-meshheading:9574553-... | lld:pubmed |
| pubmed-article:9574553 | pubmed:meshHeading | pubmed-meshheading:9574553-... | lld:pubmed |
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| pubmed-article:9574553 | pubmed:meshHeading | pubmed-meshheading:9574553-... | lld:pubmed |
| pubmed-article:9574553 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9574553 | pubmed:articleTitle | IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. | lld:pubmed |
| pubmed-article:9574553 | pubmed:affiliation | Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. twynn@atlas.niaid.nih.gov | lld:pubmed |
| pubmed-article:9574553 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:16153 | entrezgene:pubmed | pubmed-article:9574553 | lld:entrezgene |
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