| pubmed-article:9569997 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9569997 | lifeskim:mentions | umls-concept:C0016452 | lld:lifeskim |
| pubmed-article:9569997 | lifeskim:mentions | umls-concept:C0079399 | lld:lifeskim |
| pubmed-article:9569997 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:9569997 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:9569997 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9569997 | lifeskim:mentions | umls-concept:C0533453 | lld:lifeskim |
| pubmed-article:9569997 | lifeskim:mentions | umls-concept:C2827666 | lld:lifeskim |
| pubmed-article:9569997 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9569997 | pubmed:dateCreated | 1998-6-8 | lld:pubmed |
| pubmed-article:9569997 | pubmed:abstractText | The objectives of this study were to assess the effect of food and gender on the pharmacokinetics of avitripan. A group of 12 healthy men and 12 healthy women was administered a single 50 mg dose of avitriptan capsule under fasting conditions and 5 min after a high-fat breakfast. The two treatments were repeated in a replicate design to assess the intra-subject variability in the pharmacokinetics of avitriptan under fasted and fed conditions. There was a 1 week washout between treatments. Serial blood samples were collected over 24 h after dosing and analyzed by a validated HPLC method for avitriptan. The mean (SD) peak concentrations (Cmax) were 168 (86.4) ng mL-1 in the fasted condition and 57.3 (34.8) ng mL-1 in the fed condition in males and females combined. The corresponding areas under the plasma concentration curve (AUC) were 335 (162) and 185 (64.5) ng h mL-1, respectively. Both Cmax and AUC were significantly reduced in the fed condition. In addition, the time to peak concentration (tmax) was significantly delayed from a median of 45 min to 2 h after the high-fat breakfast. The clinical significance of this food effect is unclear at the present time. There were no gender differences nor a gender by food interaction in the pharmacokinetics of avitriptan. The intra- and inter-subject variability (%CV) in the Cmax and AUC of avitriptan in the fasted and fed conditions ranged from 10 to 60% in male and female subjects. | lld:pubmed |
| pubmed-article:9569997 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9569997 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9569997 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9569997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9569997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9569997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9569997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9569997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9569997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9569997 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9569997 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9569997 | pubmed:issn | 0142-2782 | lld:pubmed |
| pubmed-article:9569997 | pubmed:author | pubmed-author:BarbhaiyaR... | lld:pubmed |
| pubmed-article:9569997 | pubmed:author | pubmed-author:LeeJ SJS | lld:pubmed |
| pubmed-article:9569997 | pubmed:author | pubmed-author:GreeneD SDS | lld:pubmed |
| pubmed-article:9569997 | pubmed:author | pubmed-author:MaratheP HPH | lld:pubmed |
| pubmed-article:9569997 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9569997 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:9569997 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9569997 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9569997 | pubmed:pagination | 153-7 | lld:pubmed |
| pubmed-article:9569997 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:9569997 | pubmed:meshHeading | pubmed-meshheading:9569997-... | lld:pubmed |
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| pubmed-article:9569997 | pubmed:meshHeading | pubmed-meshheading:9569997-... | lld:pubmed |
| pubmed-article:9569997 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9569997 | pubmed:articleTitle | Assessment of effect of food, gender, and intra-subject variability in the pharmacokinetics of avitriptan. | lld:pubmed |
| pubmed-article:9569997 | pubmed:affiliation | Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Princeton, NJ, USA. Punit_H._Marathe@ccmail.bms.com | lld:pubmed |
| pubmed-article:9569997 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9569997 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9569997 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9569997 | lld:pubmed |
