| pubmed-article:9568913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C0043309 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C0010423 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:9568913 | lifeskim:mentions | umls-concept:C0439611 | lld:lifeskim |
| pubmed-article:9568913 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9568913 | pubmed:dateCreated | 1998-6-4 | lld:pubmed |
| pubmed-article:9568913 | pubmed:abstractText | A variant of human interferon-gamma (IFN-gamma) has been created in which the two chains of the homodimeric cytokine were linked N- to C-terminus by an eight residue polypeptide linker. The sequence of this linker was derived from a loop in bira bifunctional protein, and was determined from a structural database search. This "single-chain" variant was used to create an IFN-gamma molecule that binds only a single copy of the alpha-chain receptor, rather than the 2 alpha-chain receptor: 1 IFN-gamma binding stoichiometry observed for the native hormone. Crystals have been grown of a 1:1 complex between this single-chain molecule and the extracellular domain of its alpha-chain receptor. These crystals diffract beyond 2.0 A, significantly better than the 2.9 A observed for the native 2:1 complex. Density calculations suggest these crystals contain two complexes in the asymmetric unit; a self-rotation function confirms this conclusion. | lld:pubmed |
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| pubmed-article:9568913 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9568913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9568913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9568913 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9568913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9568913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9568913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9568913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9568913 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9568913 | pubmed:issn | 0961-8368 | lld:pubmed |
| pubmed-article:9568913 | pubmed:author | pubmed-author:KossiakoffA... | lld:pubmed |
| pubmed-article:9568913 | pubmed:author | pubmed-author:RandauDD | lld:pubmed |
| pubmed-article:9568913 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9568913 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:9568913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9568913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9568913 | pubmed:pagination | 1057-60 | lld:pubmed |
| pubmed-article:9568913 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9568913 | pubmed:meshHeading | pubmed-meshheading:9568913-... | lld:pubmed |
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| pubmed-article:9568913 | pubmed:meshHeading | pubmed-meshheading:9568913-... | lld:pubmed |
| pubmed-article:9568913 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9568913 | pubmed:articleTitle | Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor. | lld:pubmed |
| pubmed-article:9568913 | pubmed:affiliation | Graduate Group in Biophysics, University of California, San Francisco 94000, USA. | lld:pubmed |
| pubmed-article:9568913 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9568913 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9568913 | lld:pubmed |
