| pubmed-article:9566702 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9566702 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9566702 | lifeskim:mentions | umls-concept:C0038880 | lld:lifeskim |
| pubmed-article:9566702 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:9566702 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:9566702 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9566702 | pubmed:dateCreated | 1998-5-8 | lld:pubmed |
| pubmed-article:9566702 | pubmed:abstractText | We have demonstrated for the first time that suramin is taken up by human dermal microvascular endothelial (HMEC-1) cells by an active process involving the caveolae system. The uptake of suramin was time-dependent and reduced by more than 90% when incubated in the presence of albumin or at 4 degrees C. Suramin uptake was also inhibited when incubated in the presence of filipin and digitonin, both potent cholesterol-binding agents, but not in the presence of probenecid. The [3H]suramin taken up by the HMEC-1 cells was located primarily within the nucleus, followed by the cytoplasmic fraction. The presence of suramin in these cellular compartments suggests that this drug may act through intracellular mechanisms. | lld:pubmed |
| pubmed-article:9566702 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9566702 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9566702 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9566702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9566702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9566702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9566702 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9566702 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9566702 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:9566702 | pubmed:author | pubmed-author:CollinsD CDC | lld:pubmed |
| pubmed-article:9566702 | pubmed:author | pubmed-author:TaylorM FMF | lld:pubmed |
| pubmed-article:9566702 | pubmed:author | pubmed-author:GagliardiA... | lld:pubmed |
| pubmed-article:9566702 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9566702 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:9566702 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:9566702 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9566702 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9566702 | pubmed:pagination | 97-102 | lld:pubmed |
| pubmed-article:9566702 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9566702 | pubmed:meshHeading | pubmed-meshheading:9566702-... | lld:pubmed |
| pubmed-article:9566702 | pubmed:meshHeading | pubmed-meshheading:9566702-... | lld:pubmed |
| pubmed-article:9566702 | pubmed:meshHeading | pubmed-meshheading:9566702-... | lld:pubmed |
| pubmed-article:9566702 | pubmed:meshHeading | pubmed-meshheading:9566702-... | lld:pubmed |
| pubmed-article:9566702 | pubmed:meshHeading | pubmed-meshheading:9566702-... | lld:pubmed |
| pubmed-article:9566702 | pubmed:meshHeading | pubmed-meshheading:9566702-... | lld:pubmed |
| pubmed-article:9566702 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9566702 | pubmed:articleTitle | Uptake of suramin by human microvascular endothelial cells. | lld:pubmed |
| pubmed-article:9566702 | pubmed:affiliation | Veterans Affairs Medical Center and the Department of Obstetrics and Gynecology, University of Kentucky Medical Center, Lexington 40536-0305, USA. | lld:pubmed |
| pubmed-article:9566702 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9566702 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9566702 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9566702 | lld:pubmed |
