| pubmed-article:9564602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9564602 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:9564602 | lifeskim:mentions | umls-concept:C0026454 | lld:lifeskim |
| pubmed-article:9564602 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:9564602 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:9564602 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:9564602 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:9564602 | pubmed:dateCreated | 1998-6-10 | lld:pubmed |
| pubmed-article:9564602 | pubmed:abstractText | MAO-A and -B are defined by their substrate and inhibitor preferences. To determine which regions of the isoenzymes confer these preferences, we have constructed six chimeric MAO enzymes by reciprocally exchanging corresponding N-terminal, C-terminal, and internal segments of MAO-A and -B then determined the catalytic properties of these chimeric enzymes. N-terminal chimerics A45B and B36A were made by exchanging amino acid segments 1-45 and 1-36 of MAO-A and -B respectively. C-terminal chimerics A402B and B393A were made by exchanging amino acid segments 403-527 and 394-520 of MAO-A and -B respectively, and internal chimerics AB161-375A and BA152-366B were made by exchanging amino acid segments 161-375 and 152-366 of MAO-A and -B respectively. The enzymatic properties observed for the chimerics suggest that the exchanged internal regions but not the N- or C-terminal regions confer substrate and inhibitor preferences. | lld:pubmed |
| pubmed-article:9564602 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9564602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9564602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9564602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9564602 | pubmed:issn | 0303-6995 | lld:pubmed |
| pubmed-article:9564602 | pubmed:author | pubmed-author:ShihJ CJC | lld:pubmed |
| pubmed-article:9564602 | pubmed:author | pubmed-author:FORTD JDJ | lld:pubmed |
| pubmed-article:9564602 | pubmed:author | pubmed-author:GehaR MRM | lld:pubmed |
| pubmed-article:9564602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9564602 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:9564602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9564602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9564602 | pubmed:pagination | 1-8 | lld:pubmed |
| pubmed-article:9564602 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:meshHeading | pubmed-meshheading:9564602-... | lld:pubmed |
| pubmed-article:9564602 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9564602 | pubmed:articleTitle | Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities. | lld:pubmed |
| pubmed-article:9564602 | pubmed:affiliation | Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, USA. | lld:pubmed |
| pubmed-article:9564602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9564602 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9564602 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9564602 | lld:pubmed |
