| pubmed-article:9560294 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9560294 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:9560294 | lifeskim:mentions | umls-concept:C0083031 | lld:lifeskim |
| pubmed-article:9560294 | lifeskim:mentions | umls-concept:C0082758 | lld:lifeskim |
| pubmed-article:9560294 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:9560294 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9560294 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:9560294 | lifeskim:mentions | umls-concept:C2348205 | lld:lifeskim |
| pubmed-article:9560294 | pubmed:dateCreated | 1998-10-26 | lld:pubmed |
| pubmed-article:9560294 | pubmed:abstractText | The transmembrane glycoprotein gp130 is involved in many cytokine-mediated cellular responses and acts therein as the signal transducing receptor subunit. Interleukin-6 (IL-6) and interleukin-11 (IL-11), in complex with their specific alpha-receptors, homodimerize gp130 and, as a consequence, activate the Janus kinase (Jak)/signal transducer and activator of transcription (STAT) signalling pathway in their target cells. So far, it is not clear whether gp130 is bound to these cytokines and their specific alpha-receptor subunits through identical or different epitopes. In order to study the interaction of IL-11 and IL-11R with human gp130 the soluble form of the recently cloned human IL-11R was expressed in baculovirus-infected insect cells. By a coprecipitation binding-assay it is demonstrated that IL-11 and IL-6 compete for binding to gp130. Using deletion and point mutants of gp130 it is shown that IL-11-IL-11R and IL-6-IL-6R recognize overlapping binding motifs on gp130. Moreover, using well-established Jak-deficient cell lines we demonstrate that STAT activation by IL-11 requires Jak1. Taken together, our data support the concept that IL-6 and IL-11 activate gp130 by very similar molecular mechanisms. | lld:pubmed |
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| pubmed-article:9560294 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9560294 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9560294 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9560294 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9560294 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9560294 | pubmed:month | May | lld:pubmed |
| pubmed-article:9560294 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:9560294 | pubmed:author | pubmed-author:HeinrichP CPC | lld:pubmed |
| pubmed-article:9560294 | pubmed:author | pubmed-author:JacquesYY | lld:pubmed |
| pubmed-article:9560294 | pubmed:author | pubmed-author:KerrI MIM | lld:pubmed |
| pubmed-article:9560294 | pubmed:author | pubmed-author:CilibertiAA | lld:pubmed |
| pubmed-article:9560294 | pubmed:author | pubmed-author:MinvielleSS | lld:pubmed |
| pubmed-article:9560294 | pubmed:author | pubmed-author:Müller-NewenG... | lld:pubmed |
| pubmed-article:9560294 | pubmed:author | pubmed-author:KüsterAA | lld:pubmed |
