| pubmed-article:9560188 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C0063690 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C0600499 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C2825311 | lld:lifeskim |
| pubmed-article:9560188 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:9560188 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9560188 | pubmed:dateCreated | 1998-6-4 | lld:pubmed |
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| pubmed-article:9560188 | pubmed:abstractText | The x-ray structures of an inhibitor complex of the catalytic core domain of avian sarcoma virus integrase (ASV IN) were solved at 1.9- to 2.0-A resolution at two pH values, with and without Mn2+ cations. This inhibitor (Y-3), originally identified in a screen for inhibitors of the catalytic activity of HIV type 1 integrase (HIV-1 IN), was found in the present study to be active against ASV IN as well as HIV-1 IN. The Y-3 molecule is located in close proximity to the enzyme active site, interacts with the flexible loop, alters loop conformation, and affects the conformations of active site residues. As crystallized, a Y-3 molecule stacks against its symmetry-related mate. Preincubation of IN with metal cations does not prevent inhibition, and Y-3 binding does not prevent binding of divalent cations to IN. Three compounds chemically related to Y-3 also were investigated, but no binding was observed in the crystals. Our results identify the structural elements of the inhibitor that likely determine its binding properties. | lld:pubmed |
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| pubmed-article:9560188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9560188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9560188 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9560188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9560188 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9560188 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:MerkerAA | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:YanoNN | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:SkalkaA MAM | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:WlodawerAA | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:BurkeT RTRJr | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:ZhaoHH | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:PommierYY | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:NeamatiNN | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:AlexandratosJ... | lld:pubmed |
| pubmed-article:9560188 | pubmed:author | pubmed-author:LubkowskiJJ | lld:pubmed |
| pubmed-article:9560188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9560188 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:9560188 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9560188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9560188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9560188 | pubmed:pagination | 4831-6 | lld:pubmed |
| pubmed-article:9560188 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9560188 | pubmed:meshHeading | pubmed-meshheading:9560188-... | lld:pubmed |
| pubmed-article:9560188 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9560188 | pubmed:articleTitle | Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. | lld:pubmed |
| pubmed-article:9560188 | pubmed:affiliation | Macromolecular Structure Laboratory, Advanced BioScience Laboratories-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. | lld:pubmed |
| pubmed-article:9560188 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9560188 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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