| pubmed-article:9553137 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:9553137 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:9553137 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:9553137 | lifeskim:mentions | umls-concept:C0664773 | lld:lifeskim |
| pubmed-article:9553137 | lifeskim:mentions | umls-concept:C1334142 | lld:lifeskim |
| pubmed-article:9553137 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9553137 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:9553137 | pubmed:dateCreated | 1998-5-22 | lld:pubmed |
| pubmed-article:9553137 | pubmed:abstractText | We recently cloned IRS-4, a new member of the insulin receptor substrate (IRS) family. In this study we have characterized IRS-4 in human embryonic kidney 293 cells, where it was originally discovered. IRS-4 was the predominant insulin-elicited phosphotyrosine protein in these cells. Subcellular fractionation revealed that about 50% of IRS-4 was located in cellular membranes, and immunofluorescence indicated that IRS-4 was concentrated at the plasma membrane. Immunoelectron microscopy conclusively established that a large portion of the IRS-4 was located at the cytoplasmic surface of the plasma membrane in both the unstimulated and insulin-treated states. IRS-4 was found to be associated with two src homology 2 (SH2) domain-containing proteins, phosphatidylinositol 3-kinase and Grb2, the adaptor to the guanine nucleotide exchange factor for Ras. On the other hand, no significant association was detected with two other SH2 domain proteins, the SH2-containing protein tyrosine phosphatase 2 and phospholipase Cgamma. Insulin-like growth factor I acting through its receptor was as effective as insulin in eliciting tyrosine phosphorylation of IRS-4, but interleukin 4 and epidermal growth factor were ineffective. | lld:pubmed |
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| pubmed-article:9553137 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9553137 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9553137 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9553137 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9553137 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9553137 | pubmed:author | pubmed-author:SlotJ WJW | lld:pubmed |
| pubmed-article:9553137 | pubmed:author | pubmed-author:LienhardG EGE | lld:pubmed |
| pubmed-article:9553137 | pubmed:author | pubmed-author:KellerS RSR | lld:pubmed |
| pubmed-article:9553137 | pubmed:author | pubmed-author:LavanB EBE | lld:pubmed |
| pubmed-article:9553137 | pubmed:author | pubmed-author:FantinV RVR | lld:pubmed |
| pubmed-article:9553137 | pubmed:author | pubmed-author:SparlingJ DJD | lld:pubmed |
| pubmed-article:9553137 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9553137 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9553137 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9553137 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9553137 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9553137 | pubmed:pagination | 10726-32 | lld:pubmed |
| pubmed-article:9553137 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9553137 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9553137 | pubmed:articleTitle | Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. | lld:pubmed |
| pubmed-article:9553137 | pubmed:affiliation | Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. | lld:pubmed |
| pubmed-article:9553137 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9553137 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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