| pubmed-article:9547386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9547386 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:9547386 | lifeskim:mentions | umls-concept:C2339371 | lld:lifeskim |
| pubmed-article:9547386 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9547386 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:9547386 | lifeskim:mentions | umls-concept:C0182537 | lld:lifeskim |
| pubmed-article:9547386 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:9547386 | pubmed:dateCreated | 1998-7-16 | lld:pubmed |
| pubmed-article:9547386 | pubmed:abstractText | 1. The whole-cell patch clamp was employed to study Na+-K+ pump current (Ip) in acutely isolated myocytes. alpha-Adrenergic receptors were activated with noradrenaline (NA) after blocking beta-adrenergic receptors with propranolol. Ip was measured as the current blocked by strophanthidin (Str). 2. Activation of alpha-receptors by NA increased Ip in a concentration-dependent manner. The K0.5 depended on intracellular calcium ([Ca2+]i), however maximal stimulation did not. At 15 nM [Ca2+]i the K0.5 was 219 nM NA whereas at 1.4 microM [Ca2+]i it was 3 nM. 3. The voltage dependence of Ip was not shifted by NA at either high or low [Ca2+]i. At each voltage, maximal stimulation of Ip was 14-15 %. 4. Staurosporine (St), an inhibitor of protein kinase C (PKC), eliminated the alpha-receptor-mediated stimulation of Ip at either high or low[Ca2+]i. 5. The stimulation of Ip was independent of changes in intracellular sodium or external potassium concentrations, and did not reflect a change in affinity for Str. 6. Phenylephrine, methoxamine and metaraminol, three selective alpha1-adrenergic agonists, stimulate Ip in a similar manner to NA. Stimulation of Ip by NA was eliminated by prazosin, an alpha1-antagonist, but was unaffected by yohimbine, an alpha2-antagonist. 7. We conclude noradrenaline activates ventricular alpha1-receptors, which are specifically coupled via PKC to increase Na+-K+ pump current. The sensitivity of the coupling is [Ca2+]i dependent, however the maximal increase in pump current is [Ca2+]i and voltage independent. | lld:pubmed |
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| pubmed-article:9547386 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9547386 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9547386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9547386 | pubmed:month | May | lld:pubmed |
| pubmed-article:9547386 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9547386 | pubmed:author | pubmed-author:CohenI SIS | lld:pubmed |
| pubmed-article:9547386 | pubmed:author | pubmed-author:WangYY | lld:pubmed |
| pubmed-article:9547386 | pubmed:author | pubmed-author:MathiasR TRT | lld:pubmed |
| pubmed-article:9547386 | pubmed:author | pubmed-author:SudVV | lld:pubmed |
| pubmed-article:9547386 | pubmed:author | pubmed-author:GalMM | lld:pubmed |
| pubmed-article:9547386 | pubmed:author | pubmed-author:BaldoG JGJ | lld:pubmed |
| pubmed-article:9547386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9547386 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9547386 | pubmed:volume | 509 ( Pt 1) | lld:pubmed |
| pubmed-article:9547386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9547386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9547386 | pubmed:pagination | 117-28 | lld:pubmed |
| pubmed-article:9547386 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9547386 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9547386 | pubmed:articleTitle | alpha-Adrenergic effects on Na+-K+ pump current in guinea-pig ventricular myocytes. | lld:pubmed |
| pubmed-article:9547386 | pubmed:affiliation | Department of Physiology & Biophysics, State University of New York at Stony Brook, NY 11794-8661, USA. | lld:pubmed |
| pubmed-article:9547386 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9547386 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9547386 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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