| pubmed-article:9541583 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C0242632 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C1420813 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9541583 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9541583 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9541583 | pubmed:dateCreated | 1998-4-23 | lld:pubmed |
| pubmed-article:9541583 | pubmed:abstractText | Our present study provides evidence that the 4-1BB signal is critical to CD28 co-stimulation in maintaining T cell activation when CD28 has been down-regulated because of repeated stimulation. The 4-1BB signal synergized with CD28 co-stimulation by lowering the threshold of anti-CD28 required to sustain proliferation and IL-2 production. The 4-1BB signal also modulated CD28-mediated cytokine profiles by markedly enhancing Th1 but suppressing Th2-type cytokine production. The 4-1BB signal generated Th1-type cells, as identified by intracellular IFN-gamma production. IFN-gamma induction was detected preferentially in 4-1BB-expressing cells, but not in those expressing CD30. 4-1BB and CD30 were induced in both CD4+ and CD8+ cells, but the location of the two molecules was mutually exclusive in each T cell subset. Our study suggests that the 4-1BB signal regulates CD28 co-stimulation in the targeted subset cells to favor Th1 development and maintain long-term cell growth. | lld:pubmed |
| pubmed-article:9541583 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541583 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541583 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9541583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541583 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9541583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9541583 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9541583 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9541583 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:9541583 | pubmed:author | pubmed-author:MOER ERE | lld:pubmed |
| pubmed-article:9541583 | pubmed:author | pubmed-author:KwonB SBS | lld:pubmed |
| pubmed-article:9541583 | pubmed:author | pubmed-author:KimY JYJ | lld:pubmed |
| pubmed-article:9541583 | pubmed:author | pubmed-author:MantelPP | lld:pubmed |
| pubmed-article:9541583 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9541583 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:9541583 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9541583 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9541583 | pubmed:pagination | 881-90 | lld:pubmed |
| pubmed-article:9541583 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9541583 | pubmed:meshHeading | pubmed-meshheading:9541583-... | lld:pubmed |
| pubmed-article:9541583 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9541583 | pubmed:articleTitle | Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses. | lld:pubmed |
| pubmed-article:9541583 | pubmed:affiliation | Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, USA. | lld:pubmed |
| pubmed-article:9541583 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9541583 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:3604 | entrezgene:pubmed | pubmed-article:9541583 | lld:entrezgene |
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