| pubmed-article:9538130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9538130 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:9538130 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:9538130 | lifeskim:mentions | umls-concept:C0815000 | lld:lifeskim |
| pubmed-article:9538130 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:9538130 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:9538130 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:9538130 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9538130 | pubmed:dateCreated | 1998-6-2 | lld:pubmed |
| pubmed-article:9538130 | pubmed:abstractText | We have examined antitumor effect of murine neuroblastoma cells (C1300) retrovirally transduced with interleukin-4 (IL-4) gene in syngeneic A/J and nude mice. Although in vitro proliferation of IL-4-secreting C1300 cells (C1300/IL-4) was not different from that of wild-type cells, the in vivo tumor growth of C1300/IL-4 cells subcutaneously inoculated into immunocompetent A/J mice was retarded compared with that of wild-type cells and consequently, the survival of the A/J mice which received C1300/IL-4 cells was prolonged. In immunodeficient nude mice we observed accelerated growth rate of wild-type tumors in comparison with the tumors developed in A/J mice. In contrast, the tumor growth of C1300/IL-4 cells in nude mice was significantly suppressed and the growth was much slower than that of C1300/IL-4 cells inoculated in A/J mice. Thus, the secretion of IL-4 from tumor cells produced antitumor effect more efficiently in mature T cell-defective hosts than in immunocompetent mice. Our results suggest a possible clinical application of IL-4 expression in tumor cells via genetic manipulations especially in immunocompromised cancer patients. | lld:pubmed |
| pubmed-article:9538130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9538130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9538130 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9538130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9538130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9538130 | pubmed:month | May | lld:pubmed |
| pubmed-article:9538130 | pubmed:issn | 1019-6439 | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:YoshidaHH | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:TagawaMM | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:TanabeMM | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:EnomotoHH | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:TakenagaKK | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:SakiyamaSS | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:OhnumaNN | lld:pubmed |
| pubmed-article:9538130 | pubmed:author | pubmed-author:MiyauchiMM | lld:pubmed |
| pubmed-article:9538130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9538130 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:9538130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9538130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9538130 | pubmed:pagination | 1067-71 | lld:pubmed |
| pubmed-article:9538130 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:meshHeading | pubmed-meshheading:9538130-... | lld:pubmed |
| pubmed-article:9538130 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9538130 | pubmed:articleTitle | Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice. | lld:pubmed |
| pubmed-article:9538130 | pubmed:affiliation | Department of Pediatric Surgery, Chiba University, School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. | lld:pubmed |
| pubmed-article:9538130 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9538130 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16189 | entrezgene:pubmed | pubmed-article:9538130 | lld:entrezgene |
