| pubmed-article:9537413 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9537413 | lifeskim:mentions | umls-concept:C0242613 | lld:lifeskim |
| pubmed-article:9537413 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9537413 | lifeskim:mentions | umls-concept:C1520007 | lld:lifeskim |
| pubmed-article:9537413 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9537413 | pubmed:dateCreated | 1998-4-23 | lld:pubmed |
| pubmed-article:9537413 | pubmed:abstractText | Stable transduction of mammalian cells typically involves random integration of viral vectors by non-homologous recombination. Here we report that vectors based on adeno-associated virus (AAV) can efficiently modify homologous human chromosomal target sequences. Both integrated neomycin phosphotransferase genes and the hypoxanthine phosphoribosyltransferase gene were targeted by AAV vectors. Site-specific genetic modifications could be introduced into approximately 1% of cells, with the highest targeting rates occurring in normal human fibroblasts. These results suggest that AAV vectors could be used to introduce specific genetic changes into the genomic DNA of a wide variety of mammalian cells, including therapeutic gene targeting applications. | lld:pubmed |
| pubmed-article:9537413 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9537413 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9537413 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9537413 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9537413 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9537413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9537413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9537413 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9537413 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9537413 | pubmed:issn | 1061-4036 | lld:pubmed |
| pubmed-article:9537413 | pubmed:author | pubmed-author:RussellD WDW | lld:pubmed |
| pubmed-article:9537413 | pubmed:author | pubmed-author:HirataR KRK | lld:pubmed |
| pubmed-article:9537413 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9537413 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9537413 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9537413 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9537413 | pubmed:pagination | 325-30 | lld:pubmed |
| pubmed-article:9537413 | pubmed:dateRevised | 2011-1-31 | lld:pubmed |
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| pubmed-article:9537413 | pubmed:meshHeading | pubmed-meshheading:9537413-... | lld:pubmed |
| pubmed-article:9537413 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9537413 | pubmed:articleTitle | Human gene targeting by viral vectors. | lld:pubmed |
| pubmed-article:9537413 | pubmed:affiliation | Markey Molecular Medicine Center, Department of Medicine, University of Washington School of Medicine, Seattle 98195-7720, USA. drussell@u.washington.edu | lld:pubmed |
| pubmed-article:9537413 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9537413 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9537413 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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