| pubmed-article:9531338 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9531338 | lifeskim:mentions | umls-concept:C0221145 | lld:lifeskim |
| pubmed-article:9531338 | lifeskim:mentions | umls-concept:C0392386 | lld:lifeskim |
| pubmed-article:9531338 | lifeskim:mentions | umls-concept:C0245726 | lld:lifeskim |
| pubmed-article:9531338 | lifeskim:mentions | umls-concept:C1417683 | lld:lifeskim |
| pubmed-article:9531338 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9531338 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9531338 | pubmed:dateCreated | 1998-5-4 | lld:pubmed |
| pubmed-article:9531338 | pubmed:abstractText | The expression of CD29, CD61, CD18 and CD11a on platelets was examined by flow cytometry in mice treated with leukaemia inhibitory factor (LIF) or megakaryocyte growth and development factor (PEG-rHuMGDF or mpl-ligand). Treatment for 7-14 d with PEG-rHuMGDF or LIF increased the number of platelets in peripheral blood from 0.9 up to <2.0 x 10(6)/microl. These treatments decreased the expression of CD11a and CD18, whereas that of CD29 or CD61 was not markedly changed. Study after various doses or times of PEG-rHuMGDF administration indicated that a decrease of CD18 expression occurred when platelet counts started to rise. Platelet RNA content was increased in mice treated with PEG-rHuMGDF but double staining indicated that expression of CD18 was not correlated with RNA content. To evaluate integrin expression as a function of time in circulation, platelets were biotinylated in vivo. In normal or PEG-rHuMGDF-treated mice, the expression of CD29 or CD61 did not change, whereas that of CD18 decreased significantly as a function of time in circulation. These findings indicate, firstly, that stimulation of thrombocytopoiesis leads to the release of platelets with a low content of beta2 integrin and, secondly, that this integrin is also selectively lost while in the circulation. | lld:pubmed |
| pubmed-article:9531338 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9531338 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531338 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9531338 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9531338 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:9531338 | pubmed:author | pubmed-author:PiguetP FPF | lld:pubmed |
| pubmed-article:9531338 | pubmed:author | pubmed-author:GutMM | lld:pubmed |
| pubmed-article:9531338 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9531338 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:9531338 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9531338 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9531338 | pubmed:pagination | 712-9 | lld:pubmed |
| pubmed-article:9531338 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9531338 | pubmed:meshHeading | pubmed-meshheading:9531338-... | lld:pubmed |
| pubmed-article:9531338 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9531338 | pubmed:articleTitle | Stimulation of thrombocytopoiesis decreases platelet beta2 but not beta1 or beta3 integrins. | lld:pubmed |
| pubmed-article:9531338 | pubmed:affiliation | Amgen Inc., Thousand Oaks, California, USA. | lld:pubmed |
| pubmed-article:9531338 | pubmed:publicationType | Journal Article | lld:pubmed |
