| pubmed-article:9527790 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9527790 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:9527790 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:9527790 | lifeskim:mentions | umls-concept:C0071321 | lld:lifeskim |
| pubmed-article:9527790 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9527790 | pubmed:dateCreated | 1998-3-31 | lld:pubmed |
| pubmed-article:9527790 | pubmed:abstractText | We have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-severe combined immunodeficient (Hu-PBL-SCID) mouse model of human AIDS. The present report documents in a side-by-side comparison the superior in vitro anti-HIV-1 activity of TXU-PAP compared to the activities of zidovudine, 2',3'-didehydro-2',3'-dideoxythymidine, unconjugated PAP, and B53-PAP, an anti-CD4-PAP immunoconjugate. Notably, TXU-PAP elicited potent anti-HIV activity in the Hu-PBL-SCID mouse model of human AIDS without any side effects and at doses that were very well tolerated by cynomolgus monkeys. Furthermore, plasma samples from TXU-PAP-treated cynomolgus monkeys showed potent anti-HIV-1 activity in vitro. | lld:pubmed |
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| pubmed-article:9527790 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9527790 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9527790 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9527790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9527790 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9527790 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:9527790 | pubmed:author | pubmed-author:IrvinJ DJD | lld:pubmed |
| pubmed-article:9527790 | pubmed:author | pubmed-author:MyersD EDE | lld:pubmed |
| pubmed-article:9527790 | pubmed:author | pubmed-author:UckunF MFM | lld:pubmed |
| pubmed-article:9527790 | pubmed:author | pubmed-author:ChelstromL... | lld:pubmed |
| pubmed-article:9527790 | pubmed:author | pubmed-author:Tuel-AhlgrenL... | lld:pubmed |
| pubmed-article:9527790 | pubmed:author | pubmed-author:DibirdikII | lld:pubmed |
| pubmed-article:9527790 | pubmed:author | pubmed-author:LanglieM CMC | lld:pubmed |
| pubmed-article:9527790 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9527790 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:9527790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9527790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9527790 | pubmed:pagination | 383-8 | lld:pubmed |
| pubmed-article:9527790 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9527790 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9527790 | pubmed:articleTitle | TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus. | lld:pubmed |
| pubmed-article:9527790 | pubmed:affiliation | Wayne Hughes Institute, St. Paul, Minnesota 55113, USA. faith_uckun@mercury.ih.org | lld:pubmed |
| pubmed-article:9527790 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9527790 | pubmed:publicationType | Comparative Study | lld:pubmed |
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