| pubmed-article:9526008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9526008 | lifeskim:mentions | umls-concept:C0051403 | lld:lifeskim |
| pubmed-article:9526008 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9526008 | pubmed:dateCreated | 1998-4-20 | lld:pubmed |
| pubmed-article:9526008 | pubmed:abstractText | alpha-Latrotoxin (alpha-Ltx), a component of black widow spider venom, stimulates secretion from nerve terminals and from PC12 cells. In this study we examine the effects of expression of a newly cloned Ca2+-independent receptor for alpha-Ltx (CIRL) on secretion from bovine chromaffin cells. We first characterized the effect of alpha-Ltx on secretion from untransfected cells. alpha-Ltx, by binding in a Ca2+-independent manner to an endogenous receptor, causes subsequent Ca2+-dependent secretion from intact cells. The stimulation of secretion is correlated with Ca2+ influx caused by the toxin. In permeabilized cells in which the Ca2+ concentration is regulated by buffer, alpha-Ltx also enhances Ca2+-dependent secretion, indicating a direct role of the endogenous receptor in the secretory pathway. Expression of CIRL increased the sensitivity of intact and permeabilized cells to the effects of alpha-Ltx, demonstrating that this protein is functional in coupling to secretion. Importantly, in the absence of alpha-Ltx, the expression of CIRL specifically inhibited the ATP-dependent component of secretion in permeabilized cells without affecting the ATP-independent secretion. This suggests that this receptor modulates the normal function of the regulated secretory pathway and that alpha-Ltx may act by reversing the inhibitory effects of the receptor. | lld:pubmed |
| pubmed-article:9526008 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9526008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9526008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9526008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9526008 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9526008 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:9526008 | pubmed:author | pubmed-author:HolzR WRW | lld:pubmed |
| pubmed-article:9526008 | pubmed:author | pubmed-author:PetrenkoA GAG | lld:pubmed |
| pubmed-article:9526008 | pubmed:author | pubmed-author:BittnerM AMA | lld:pubmed |
| pubmed-article:9526008 | pubmed:author | pubmed-author:StuenkelE LEL | lld:pubmed |
| pubmed-article:9526008 | pubmed:author | pubmed-author:KrasnoperovV... | lld:pubmed |
| pubmed-article:9526008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9526008 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9526008 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9526008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9526008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9526008 | pubmed:pagination | 2914-22 | lld:pubmed |
| pubmed-article:9526008 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9526008 | pubmed:meshHeading | pubmed-meshheading:9526008-... | lld:pubmed |
| pubmed-article:9526008 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9526008 | pubmed:articleTitle | A Ca2+-independent receptor for alpha-latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms. | lld:pubmed |
| pubmed-article:9526008 | pubmed:affiliation | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | lld:pubmed |
| pubmed-article:9526008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9526008 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9526008 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9526008 | lld:pubmed |
