| pubmed-article:9525643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9525643 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:9525643 | lifeskim:mentions | umls-concept:C1155008 | lld:lifeskim |
| pubmed-article:9525643 | lifeskim:mentions | umls-concept:C0024282 | lld:lifeskim |
| pubmed-article:9525643 | lifeskim:mentions | umls-concept:C0376408 | lld:lifeskim |
| pubmed-article:9525643 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:9525643 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:9525643 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9525643 | pubmed:dateCreated | 1998-4-17 | lld:pubmed |
| pubmed-article:9525643 | pubmed:abstractText | Bovine leukemia virus (BLV)-induced persistent lymphocytosis is characterized by a polyclonal expansion of CD5+ B lymphocytes. To examine the role of the cytokine microenvironment in this virus-induced B-lymphocyte expansion, the expression of interleukin-2 (IL-2), IL-4, IL-10, and gamma interferon (IFN-gamma) mRNA, was measured in stimulated peripheral blood mononuclear cells from persistently lymphocytotic BLV-infected cows, nonlymphocytotic BLV-infected cows, and uninfected cows. IL-2 and IL-10 mRNA expression and IL-2 functional activity were significantly increased when peripheral blood mononuclear cells from persistently lymphocytotic cows were stimulated with concanavalin A (ConA). Additionally, during persistent lymphocytosis, peak IL-2 and IL-10 mRNA expression was delayed, and elevated expression was prolonged. To determine the potential biologic importance of increased IL-2 and IL-10 expression, the response of isolated B lymphocytes from persistently lymphocytotic cows to human recombinant cytokines and to cytokine-containing supernatants from isolated T lymphocytes was examined. While recombinant human IL-10 (rhIL-10) did not consistently induce detectable changes, rhIL-2 increased viral protein (p24) and IL-2 receptor expression in isolated B lymphocytes from persistently lymphocytotic cows. Additionally, rhIL-2 and supernatant from ConA-stimulated T lymphocytes enhanced B-lymphocyte proliferation. The stimulatory activity of the T-lymphocyte supernatant could be completely inhibited with a polyclonal anti-rhIL-2 antibody. Finally, polyclonal anti-rhIL-2 antibody, as well as anti-BLV antibody, inhibited spontaneous proliferation of peripheral blood mononuclear cells from persistently lymphocytotic cows, demonstrating that the spontaneous lymphoproliferation characteristic of BLV-induced persistent lymphocytosis is IL-2 dependent and antigen dependent. Collectively, these findings strongly suggest that increased T-lymphocyte expression of IL-2 in BLV-infected cows contributes to development and/or maintenance of persistent B lymphocytosis. | lld:pubmed |
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| pubmed-article:9525643 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9525643 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9525643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9525643 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9525643 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9525643 | pubmed:author | pubmed-author:DavisW CWC | lld:pubmed |
| pubmed-article:9525643 | pubmed:author | pubmed-author:BrownW CWC | lld:pubmed |
| pubmed-article:9525643 | pubmed:author | pubmed-author:PalmerG HGH | lld:pubmed |
| pubmed-article:9525643 | pubmed:author | pubmed-author:McElwainT FTF | lld:pubmed |
| pubmed-article:9525643 | pubmed:author | pubmed-author:StoneD MDM | lld:pubmed |
| pubmed-article:9525643 | pubmed:author | pubmed-author:TruebloodE... | lld:pubmed |
| pubmed-article:9525643 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9525643 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:9525643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9525643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9525643 | pubmed:pagination | 3169-77 | lld:pubmed |
| pubmed-article:9525643 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9525643 | pubmed:meshHeading | pubmed-meshheading:9525643-... | lld:pubmed |
| pubmed-article:9525643 | pubmed:meshHeading | pubmed-meshheading:9525643-... | lld:pubmed |
| pubmed-article:9525643 | pubmed:meshHeading | pubmed-meshheading:9525643-... | lld:pubmed |
