| pubmed-article:9524130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9524130 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:9524130 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9524130 | lifeskim:mentions | umls-concept:C0084378 | lld:lifeskim |
| pubmed-article:9524130 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:9524130 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:9524130 | lifeskim:mentions | umls-concept:C1413965 | lld:lifeskim |
| pubmed-article:9524130 | lifeskim:mentions | umls-concept:C1622990 | lld:lifeskim |
| pubmed-article:9524130 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9524130 | pubmed:dateCreated | 1998-6-1 | lld:pubmed |
| pubmed-article:9524130 | pubmed:abstractText | In order to assess the role of Prp22 in yeast pre-mRNA splicing, we have purified the 130 kDa Prp22 protein and developed an in vitro depletion/reconstitution assay. We show that Prp22 is required for the second step of actin pre-mRNA splicing. Prp22 can act on pre-assembled spliceosomes that are arrested after step 1 in an ATP-independent fashion. The requirement for Prp22 during step 2 depends on the distance between the branchpoint and the 3' splice site, suggesting a previously unrecognized role for Prp22 in splice site selection. We characterize the biochemical activities of Prp22, a member of the DExH-box family of proteins, and we show that purified recombinant Prp22 protein is an RNA-dependent ATPase and an ATP-dependent RNA helicase. Prp22 uses the energy of ATP hydrolysis to effect the release of mRNA from the spliceosome. Thus, Prp22 has two distinct functions in yeast pre-mRNA splicing: an ATP-independent role during the second catalytic step and an ATP-requiring function in disassembly of the spliceosome. | lld:pubmed |
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| pubmed-article:9524130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9524130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9524130 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9524130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9524130 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9524130 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:9524130 | pubmed:author | pubmed-author:SchwerBB | lld:pubmed |
| pubmed-article:9524130 | pubmed:author | pubmed-author:GrossC HCH | lld:pubmed |
| pubmed-article:9524130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9524130 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9524130 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9524130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9524130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9524130 | pubmed:pagination | 2086-94 | lld:pubmed |
| pubmed-article:9524130 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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