| pubmed-article:9518696 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0085080 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0178702 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:9518696 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:9518696 | pubmed:dateCreated | 1998-5-28 | lld:pubmed |
| pubmed-article:9518696 | pubmed:abstractText | 1. The cardiac muscarinic receptor-K+ channel system was reconstructed in Chinese hamster ovary (CHO) cells by transfecting the cells with the various components of the system. The activity of the muscarinic K+ channel was measured with the cell-attached configuration of the patch clamp technique. 2. In CHO cells transfected with the channel (Kir3.1/Kir3.4), receptor (hm2) and receptor kinase (GRK2), on exposure to agonist, there was a decline in channel activity as a result of desensitization, similar to that in atrial cells. 3. Whereas the desensitization was almost abolished by not transfecting with the receptor kinase or by transfecting with a mutant receptor lacking phosphorylation sites, it was only reduced (by approximately 39%) by transfecting with a mutant receptor kinase with little/kinase activity. 4. These results suggest that the receptor kinase is responsible for desensitization of the muscarinic K+ channel and that this involves phosphorylation-dependent and -independent mechanisms. | lld:pubmed |
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| pubmed-article:9518696 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9518696 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9518696 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9518696 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9518696 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9518696 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:9518696 | pubmed:author | pubmed-author:KAWAM ZMZ | lld:pubmed |
| pubmed-article:9518696 | pubmed:author | pubmed-author:BoyettM RMR | lld:pubmed |
| pubmed-article:9518696 | pubmed:author | pubmed-author:KhanI AIA | lld:pubmed |
| pubmed-article:9518696 | pubmed:author | pubmed-author:ShueVV | lld:pubmed |
| pubmed-article:9518696 | pubmed:author | pubmed-author:TsugaHH | lld:pubmed |
| pubmed-article:9518696 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9518696 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9518696 | pubmed:volume | 507 ( Pt 2) | lld:pubmed |
| pubmed-article:9518696 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9518696 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9518696 | pubmed:pagination | 325-34 | lld:pubmed |
| pubmed-article:9518696 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9518696 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9518696 | pubmed:articleTitle | Role of receptor kinase in short-term desensitization of cardiac muscarinic K+ channels expressed in Chinese hamster ovary cells. | lld:pubmed |
| pubmed-article:9518696 | pubmed:affiliation | Department of Physiology, University of Leeds, UK. | lld:pubmed |
| pubmed-article:9518696 | pubmed:publicationType | Journal Article | lld:pubmed |
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