Linked Life Data

9514092

Source:http://linkedlifedata.com/resource/pubmed/id/9514092

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pubmed-article:9514092pubmed:abstractTextAnnexin I is a phospholipid and actin binding protein which may play a role in signal transduction to the cytoskeleton. Previous work reported the differential expression of annexin I mRNA among rat adenocarcinoma cell lines of various metastatic potential (MTLn3, MTLn2, MTC.4: highest to lowest, respectively) (Pencil et al. 1993, Breast Cancer Res Treat, 25, 165-74). This relationship has been extended to the protein level in in vitro cultures using Western blotting and flow cytometry. Annexin I protein levels in MTLn3 cells are 3- to 5-fold higher than in MTC.4 cells. The weakly metastatic cell line MTLn2 shows levels 1.5- to 2.5-fold higher than MTC.4. In vivo tumors were produced by injecting 1 x 10(6) cells into mammary fat pads of syngeneic rats and necropsies were performed 40 days later. Semiquantitative immunohistochemical color image analysis was performed using a polyclonal rat annexin I specific antibody. Annexin I protein expression was highest in lung metastases of MTLn3, at 8-fold the levels observed in the MTC.4 primary tumors. MTLn3 cells in the primary tumor had an annexin I specific optical density 3-fold higher than that of cells in the MTC.4 primary tumor. MTLn2 primary tumors had an annexin I specific optical density 1.5-fold higher than MTC.4. A proportion of human mammary adenocarcinomas also have positive annexin I immunoreactivity, often with more uniform annexin I staining in the lymph node metastases. These results suggest that there may be survival advantages for nascent metastatic cells with high annexin I levels.lld:pubmed
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pubmed-article:9514092pubmed:pagination113-21lld:pubmed
pubmed-article:9514092pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9514092pubmed:articleTitleElevated levels of annexin I protein in vitro and in vivo in rat and human mammary adenocarcinoma.lld:pubmed
pubmed-article:9514092pubmed:affiliationDepartment of Pathology, University of Texas Medical Branch, Galveston 77555-0747, USA.lld:pubmed
pubmed-article:9514092pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9514092pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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