| pubmed-article:9506834 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:9506834 | lifeskim:mentions | umls-concept:C0074733 | lld:lifeskim |
| pubmed-article:9506834 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9506834 | pubmed:dateCreated | 1998-3-31 | lld:pubmed |
| pubmed-article:9506834 | pubmed:abstractText | Expression of Na+ channel protein was analysed in established cell lines of rat and human prostatic carcinoma origin by flow cytometry using a fluorescein-labelled polyclonal antibody. In many cell lines examined, the obtained frequency distribution profiles were bimodal and identified a subpopulation of cells which expressed high levels of Na+ channel protein. A significant positive correlation was demonstrated between the proportion of channel-expressing cells and the functional ability of individual cell lines to invade a basement membrane matrix in vitro. In addition, two transfectant cell lines containing rat prostate cancer genomic DNA were found to express significantly elevated levels of Na+ channel protein when compared with the original benign recipient cell line. Enhanced Na+ channel expression by two metastatic derivatives of these transfectant cells directly correlated with increased invasiveness in vitro. These studies strongly support the hypothesis that expression of Na+ channel protein and the metastatic behaviour of prostatic carcinoma cells are functionally related, either by endowing the membranes of these cells with specialised electrophysiological properties (e.g. enhancing their motility and/or secretory activities) and/or by perturbing endogenous mechanisms regulating ionic homeostasis within the cells. | lld:pubmed |
| pubmed-article:9506834 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9506834 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9506834 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9506834 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9506834 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9506834 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9506834 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9506834 | pubmed:author | pubmed-author:SmithPP | lld:pubmed |
| pubmed-article:9506834 | pubmed:author | pubmed-author:FosterC SCS | lld:pubmed |
| pubmed-article:9506834 | pubmed:author | pubmed-author:DjamgozM BMB | lld:pubmed |
| pubmed-article:9506834 | pubmed:author | pubmed-author:JuHH | lld:pubmed |
| pubmed-article:9506834 | pubmed:author | pubmed-author:FraserS PSP | lld:pubmed |
| pubmed-article:9506834 | pubmed:author | pubmed-author:ShortlandA... | lld:pubmed |
| pubmed-article:9506834 | pubmed:author | pubmed-author:RhodesN PNP | lld:pubmed |
| pubmed-article:9506834 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9506834 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:9506834 | pubmed:volume | 423 | lld:pubmed |
| pubmed-article:9506834 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9506834 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9506834 | pubmed:pagination | 19-24 | lld:pubmed |
| pubmed-article:9506834 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9506834 | pubmed:meshHeading | pubmed-meshheading:9506834-... | lld:pubmed |
| pubmed-article:9506834 | pubmed:meshHeading | pubmed-meshheading:9506834-... | lld:pubmed |
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| pubmed-article:9506834 | pubmed:meshHeading | pubmed-meshheading:9506834-... | lld:pubmed |
| pubmed-article:9506834 | pubmed:meshHeading | pubmed-meshheading:9506834-... | lld:pubmed |
| pubmed-article:9506834 | pubmed:meshHeading | pubmed-meshheading:9506834-... | lld:pubmed |
| pubmed-article:9506834 | pubmed:meshHeading | pubmed-meshheading:9506834-... | lld:pubmed |
| pubmed-article:9506834 | pubmed:meshHeading | pubmed-meshheading:9506834-... | lld:pubmed |
| pubmed-article:9506834 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9506834 | pubmed:articleTitle | Sodium channel protein expression enhances the invasiveness of rat and human prostate cancer cells. | lld:pubmed |
| pubmed-article:9506834 | pubmed:affiliation | Department of Cellular and Molecular Pathology, University of Liverpool, UK. phsmith@Liverpool.ac.uk | lld:pubmed |
| pubmed-article:9506834 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9506834 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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