| pubmed-article:9500469 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9500469 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9500469 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:9500469 | lifeskim:mentions | umls-concept:C0206528 | lld:lifeskim |
| pubmed-article:9500469 | lifeskim:mentions | umls-concept:C0178874 | lld:lifeskim |
| pubmed-article:9500469 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:9500469 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9500469 | pubmed:dateCreated | 1998-3-25 | lld:pubmed |
| pubmed-article:9500469 | pubmed:abstractText | Matrix proteolysis is thought to play a crucial role in several stages of tumor progression, including angiogenesis, and the invasion and metastasis of tumor cells. We investigated the specific role of gelatinase A (matrix metalloproteinase 2) on these events using gelatinase A-deficient mice. In these mice, tumor-induced angiogenesis was suppressed according to dorsal air sac assay. When B16-BL6 melanoma cells or Lewis lung carcinoma cells were implanted intradermally, the tumor volumes at 3 weeks after implantation in the gelatinase A-deficient mice decreased by 39% for B16-BL6 melanoma and by 24% for Lewis lung carcinoma (P < 0.03 for each tumor). The number of lung colonies of i.v. injections fell by 54% for B16-BL6 melanoma and 77% for Lewis lung carcinoma (P < 0.014 and P < 0.0015, respectively). These results indicated that host-derived gelatinase A plays an important role in angiogenesis and tumor progression, suggesting the usefulness of gelatinase A inhibitors for anticancer chemotherapy. | lld:pubmed |
| pubmed-article:9500469 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9500469 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9500469 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9500469 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9500469 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9500469 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:9500469 | pubmed:author | pubmed-author:YoshidaHH | lld:pubmed |
| pubmed-article:9500469 | pubmed:author | pubmed-author:LUNTM RMR | lld:pubmed |
| pubmed-article:9500469 | pubmed:author | pubmed-author:YoshiokaTT | lld:pubmed |
| pubmed-article:9500469 | pubmed:author | pubmed-author:NishimotoHH | lld:pubmed |
| pubmed-article:9500469 | pubmed:author | pubmed-author:ItoharaSS | lld:pubmed |
| pubmed-article:9500469 | pubmed:author | pubmed-author:TaniokaMM | lld:pubmed |
| pubmed-article:9500469 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9500469 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9500469 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:9500469 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9500469 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9500469 | pubmed:pagination | 1048-51 | lld:pubmed |
| pubmed-article:9500469 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9500469 | pubmed:meshHeading | pubmed-meshheading:9500469-... | lld:pubmed |
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| pubmed-article:9500469 | pubmed:meshHeading | pubmed-meshheading:9500469-... | lld:pubmed |
| pubmed-article:9500469 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9500469 | pubmed:articleTitle | Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. | lld:pubmed |
| pubmed-article:9500469 | pubmed:affiliation | Shionogi Institute for Medical Science, Shionogi & Co., Ltd., Osaka, Japan. takeshi.itoh@shionogi.co.jp | lld:pubmed |
| pubmed-article:9500469 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9500469 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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