| pubmed-article:9499054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0042749 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0085112 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:9499054 | lifeskim:mentions | umls-concept:C0242732 | lld:lifeskim |
| pubmed-article:9499054 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9499054 | pubmed:dateCreated | 1998-3-12 | lld:pubmed |
| pubmed-article:9499054 | pubmed:abstractText | Most individuals infected with human immunodeficiency virus type 1 (HIV-1) initially harbor macrophage-tropic, non-syncytium-inducing (M-tropic, NSI) viruses that may evolve into T-cell-tropic, syncytium-inducing viruses (T-tropic, SI) after several years. The reasons for the more efficient transmission of M-tropic, NSI viruses and the slow evolution ofT-tropic, SI viruses remain unclear, although they may be linked to expression of appropriate chemokine coreceptors for virus entry. We have examined plasma viral RNA levels and the extent of CD4+ T-cell depletion in SCID mice reconstituted with human peripheral blood leukocytes following infection with M-tropic, dual-tropic, or T-tropic HIV-1 isolates. The cell tropism was found to determine the course of viremia, with M-tropic viruses producing sustained high viral RNA levels and sparing some CD4+ T cells, dual-tropic viruses producing a transient and lower viral RNA spike and extremely rapid depletion of CD4+ T cells, and T-tropic viruses causing similarly lower viral RNA levels and rapid-intermediate rates of CD4+ T-cell depletion. A single amino acid change in the V3 region of gp120 was sufficient to cause one isolate to switch from M-tropic to dual-tropic and acquire the ability to rapidly deplete all CD4+ T cells. | lld:pubmed |
| pubmed-article:9499054 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9499054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9499054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9499054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9499054 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9499054 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9499054 | pubmed:author | pubmed-author:MosierD EDE | lld:pubmed |
| pubmed-article:9499054 | pubmed:author | pubmed-author:ChesebroBB | lld:pubmed |
| pubmed-article:9499054 | pubmed:author | pubmed-author:WehrlyKK | lld:pubmed |
| pubmed-article:9499054 | pubmed:author | pubmed-author:PicchioG RGR | lld:pubmed |
| pubmed-article:9499054 | pubmed:author | pubmed-author:GuliziaR JRJ | lld:pubmed |
| pubmed-article:9499054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9499054 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:9499054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9499054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9499054 | pubmed:pagination | 2002-9 | lld:pubmed |
| pubmed-article:9499054 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9499054 | pubmed:meshHeading | pubmed-meshheading:9499054-... | lld:pubmed |
| pubmed-article:9499054 | pubmed:meshHeading | pubmed-meshheading:9499054-... | lld:pubmed |
| pubmed-article:9499054 | pubmed:meshHeading | pubmed-meshheading:9499054-... | lld:pubmed |
| pubmed-article:9499054 | pubmed:meshHeading | pubmed-meshheading:9499054-... | lld:pubmed |
