| pubmed-article:9498757 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9498757 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:9498757 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:9498757 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:9498757 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9498757 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:9498757 | lifeskim:mentions | umls-concept:C0600191 | lld:lifeskim |
| pubmed-article:9498757 | lifeskim:mentions | umls-concept:C1512942 | lld:lifeskim |
| pubmed-article:9498757 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9498757 | pubmed:dateCreated | 1998-3-18 | lld:pubmed |
| pubmed-article:9498757 | pubmed:abstractText | Epithelial cells and lymphocytes, including gammadelta and alphabeta T cells, in the gastrointestinal tract epithelium represent a major host defense intranet that is incompletely understood. Cell-to-cell interactions between intraepithelial lymphocytes (IELs) and intestinal epithelial cells (IECs) comprise this intranet, and we have assessed the role of IECs in the regulation of gammadelta and alphabeta T cell responses. When highly purified CD3+ IEL T cells were stimulated via the TCR-CD3 complex, high proliferative responses and cytokine synthesis were induced. However, the addition of viable IECs or purified IEC membranes (mIEC) down-regulated T cell proliferative and cytokine responses. Further, the inhibitory effect of mIEC was not restored by antibodies to TGF-beta, CD1d, E-cadherin, or MHC class I or II. This inhibitory effect was noted for both gammadelta and alphabeta T cell subsets from IELs, and mRNA levels were reduced for both Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-5) cytokines in gammadelta and alphabeta IELs. In contrast, a purified membrane fraction obtained from thymocytes did not inhibit IEL proliferative responses. Further, mIEC did not inhibit splenic alphabeta T cell proliferative responses. These findings show that cell-to-cell interactions between intraepithelial gammadelta and alphabeta T cells and IECs occur via cell surface molecules, suggesting an intranet to prevent potential inflammatory responses at the intestinal mucosal surface. | lld:pubmed |
| pubmed-article:9498757 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498757 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498757 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498757 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9498757 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498757 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9498757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9498757 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9498757 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9498757 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9498757 | pubmed:author | pubmed-author:YamamotoMM | lld:pubmed |
| pubmed-article:9498757 | pubmed:author | pubmed-author:McGheeJ RJR | lld:pubmed |
| pubmed-article:9498757 | pubmed:author | pubmed-author:KiyonoHH | lld:pubmed |
| pubmed-article:9498757 | pubmed:author | pubmed-author:KawabataKK | lld:pubmed |
| pubmed-article:9498757 | pubmed:author | pubmed-author:FujihashiKK | lld:pubmed |
| pubmed-article:9498757 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9498757 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9498757 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:9498757 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9498757 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9498757 | pubmed:pagination | 2188-96 | lld:pubmed |
| pubmed-article:9498757 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9498757 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9498757 | pubmed:articleTitle | A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. | lld:pubmed |
| pubmed-article:9498757 | pubmed:affiliation | Immunobiology Vaccine Center, Department of Oral Biology, University of Alabama Medical Center, Birmingham 35294, USA. | lld:pubmed |
| pubmed-article:9498757 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9498757 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9498757 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9498757 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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