| pubmed-article:9498739 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C0008109 | lld:lifeskim |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C1332667 | lld:lifeskim |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9498739 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:9498739 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9498739 | pubmed:dateCreated | 1998-3-18 | lld:pubmed |
| pubmed-article:9498739 | pubmed:abstractText | Current models for Fas (CD95)-mediated apoptosis suggest that FLICE/caspase-8 is recruited and activated, which results in cell death. However, the role of additional molecules in Fas signaling and FLICE activation is not clear. A chimeric Fas/FLICE (F/F) receptor, containing the extracellular/transmembrane portion of Fas and the caspase region of FLICE, mediated anti-Fas apoptosis. FLICE protease subunits were generated from the F/F precursor. Killing induced by Fas, but not F/F, was blocked by a dominant negative FADD. Apoptosis triggered through Fas and F/F was inhibited by coexpression of CrmA and p35, but not Bcl-xL. F/F bypassed Fas resistance in COS-7 cells and blocking by the death effector domain (DED)-containing viral protein MC159. These results show that: 1) F/F induces cell death, indicating that FLICE activation is sufficient for apoptosis and does not require additional Fas- or FADD-binding proteins; and 2) F/F bypasses proximal defects in Fas signaling that prevent FLICE recruitment or activation. | lld:pubmed |
| pubmed-article:9498739 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9498739 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498739 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9498739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9498739 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9498739 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9498739 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9498739 | pubmed:author | pubmed-author:ZacharchukC... | lld:pubmed |
| pubmed-article:9498739 | pubmed:author | pubmed-author:HomBB | lld:pubmed |
| pubmed-article:9498739 | pubmed:author | pubmed-author:MorenoM BMB | lld:pubmed |
| pubmed-article:9498739 | pubmed:author | pubmed-author:MehraI VIV | lld:pubmed |
| pubmed-article:9498739 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9498739 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9498739 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:9498739 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9498739 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9498739 | pubmed:pagination | 2046-9 | lld:pubmed |
| pubmed-article:9498739 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9498739 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9498739 | pubmed:articleTitle | Apoptosis induced by a chimeric Fas/FLICE receptor: lack of requirement for Fas- or FADD-binding proteins. | lld:pubmed |
| pubmed-article:9498739 | pubmed:affiliation | Laboratory of Immune Cell Biology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:9498739 | pubmed:publicationType | Journal Article | lld:pubmed |
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