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pubmed-article:9498564pubmed:abstractTextThe OS-9 gene is frequently amplified in human sarcomas. We isolated and characterized an OS-9 genomic DNA from a human BAC library. Sequencing of the genomic DNA showed that the gene spanned approximately 30.4 kbp and had 15 exons. The 1,010 bp sequence of the 5' upstream region was also determined. The potential binding-sequence motifs TATA and CCAAT for general transcription factors were found in the 5' upstream region. Primer extension analysis revealed two putative transcription start sites. The significance of the 5' upstream sequence in the ubiquitous expression of the OS-9 gene in various tissues and culture cells is discussed.lld:pubmed
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pubmed-article:9498564pubmed:dateRevised2007-12-19lld:pubmed
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pubmed-article:9498564pubmed:year1997lld:pubmed
pubmed-article:9498564pubmed:articleTitleGenomic organization of the OS-9 gene amplified in human sarcomas.lld:pubmed
pubmed-article:9498564pubmed:affiliationGraduate School of Integrated Science, Yokohama City University, Yokohama.lld:pubmed
pubmed-article:9498564pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9498564pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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