| pubmed-article:9498044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C0002736 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C2936349 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C0332285 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C1705920 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C1521733 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C0018309 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C2700400 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C2348205 | lld:lifeskim |
| pubmed-article:9498044 | lifeskim:mentions | umls-concept:C0758515 | lld:lifeskim |
| pubmed-article:9498044 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9498044 | pubmed:dateCreated | 1998-4-14 | lld:pubmed |
| pubmed-article:9498044 | pubmed:abstractText | The Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is characterized by abundant neurofibrillary pathology and neuron loss. In contrast to Alzheimer's disease (AD), where extensive neurofibrillary lesions always occur with deposits of A beta in numerous amyloid plaques, A beta-rich amyloid plaques are absent or rare in most ALS/PDC patients. To characterize the amyloid plaques in the latter patients, we probed plaque-rich sections of their brains by immunohistochemistry using well-characterized antibodies to specific epitopes in the N and C termini of A beta as well as to defined epitopes in hyperphosphorylated tau (PHFtau). The results indicate that the species of A beta in the amyloid plaques of ALS/PDC patients resemble those detected in the amyloid plaques of cognitively intact subjects with pathological aging as well as patients with AD. However, the paucity of PHFtau-positive neurites in the ALS/PDC plaques suggests that they reflect pathological aging rather than AD. | lld:pubmed |
| pubmed-article:9498044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9498044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9498044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9498044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9498044 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9498044 | pubmed:issn | 0001-6322 | lld:pubmed |
| pubmed-article:9498044 | pubmed:author | pubmed-author:SchmidtM LML | lld:pubmed |
| pubmed-article:9498044 | pubmed:author | pubmed-author:PeriGG | lld:pubmed |
| pubmed-article:9498044 | pubmed:author | pubmed-author:TrojanowskiJ... | lld:pubmed |
| pubmed-article:9498044 | pubmed:author | pubmed-author:IwatsuboTT | lld:pubmed |
| pubmed-article:9498044 | pubmed:author | pubmed-author:SaiedHH | lld:pubmed |
| pubmed-article:9498044 | pubmed:author | pubmed-author:LeeV MVM | lld:pubmed |
| pubmed-article:9498044 | pubmed:author | pubmed-author:SchuckTT | lld:pubmed |
| pubmed-article:9498044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9498044 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9498044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9498044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9498044 | pubmed:pagination | 117-22 | lld:pubmed |
| pubmed-article:9498044 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:meshHeading | pubmed-meshheading:9498044-... | lld:pubmed |
| pubmed-article:9498044 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9498044 | pubmed:articleTitle | Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging. | lld:pubmed |
| pubmed-article:9498044 | pubmed:affiliation | Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia 19104-4283, USA. | lld:pubmed |
| pubmed-article:9498044 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9498044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9498044 | lld:pubmed |
